Journal of Neural Transmission

, Volume 119, Issue 6, pp 697–699

Development of Parkinson’s disease in patients with Narcolepsy

  • Chadwick W. Christine
  • William J. MarksJr.
  • Jill L. Ostrem
Movement Disorders - Short communication

DOI: 10.1007/s00702-011-0761-z

Cite this article as:
Christine, C.W., Marks, W.J. & Ostrem, J.L. J Neural Transm (2012) 119: 697. doi:10.1007/s00702-011-0761-z

Abstract

Although amphetamine drugs can damage dopaminergic axons, it is unknown whether chronic treatment with amphetamine increases the risk of developing Parkinson’s disease (PD). Of 1,152 consecutive PD patients, 3 had a prior diagnosis of narcolepsy. This rate is five times higher than expected (p = 0.02). These patients had typical onset of narcolepsy and underwent treatment with amphetamine. Although preliminary, this observation raises the possibility that some factors intrinsic to narcolepsy or its treatment may be a risk factor for PD.

Keywords

DextroamphetamineSomnolenceTreatmentRisk factor

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Chadwick W. Christine
    • 1
  • William J. MarksJr.
    • 1
  • Jill L. Ostrem
    • 1
  1. 1.Department of NeurologyUniversity of California, San FranciscoSan FranciscoUSA