Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect
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- Rabinak, C.A., Sripada, C.S., Angstadt, M. et al. J Neural Transm (2012) 119: 701. doi:10.1007/s00702-011-0747-x
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Cannabinoids affect positive and negative affective experience and emotional perception, possibly by modulating limbic brain reactivity. In this double-blind crossover, placebo-controlled functional magnetic resonance imaging study in humans, an acute oral dose of ∆9-tetrahydrocannabinol (THC) attenuated subgenual anterior cingulate cortex (sgACC) reactivity during the induction of negative affect. This observation extends prior findings implicating a cortico-limbic, emotion-related central mechanism underlying cannabinoid function.