Biological Psychiatry - Short communication

Journal of Neural Transmission

, Volume 119, Issue 6, pp 701-707

Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect

  • Christine A. RabinakAffiliated withDepartment of Psychiatry, University of MichiganMental Health Service, Veterans Affairs Ann Arbor Healthcare System
  • , Chandra Sekhar SripadaAffiliated withDepartment of Psychiatry, University of Michigan
  • , Mike AngstadtAffiliated withDepartment of Psychiatry, University of Michigan
  • , Harriet de WitAffiliated withDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago
  • , K. Luan PhanAffiliated withDepartment of Psychiatry, University of MichiganNeuroscience Program, University of MichiganMental Health Service, Veterans Affairs Ann Arbor Healthcare System Email author 

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Abstract

Cannabinoids affect positive and negative affective experience and emotional perception, possibly by modulating limbic brain reactivity. In this double-blind crossover, placebo-controlled functional magnetic resonance imaging study in humans, an acute oral dose of ∆9-tetrahydrocannabinol (THC) attenuated subgenual anterior cingulate cortex (sgACC) reactivity during the induction of negative affect. This observation extends prior findings implicating a cortico-limbic, emotion-related central mechanism underlying cannabinoid function.

Keywords

Cannabinoid Amygdala Subgenual anterior cingulate Emotion fMRI