Journal of Neural Transmission

, Volume 119, Issue 6, pp 701–707

Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect

  • Christine A. Rabinak
  • Chandra Sekhar Sripada
  • Mike Angstadt
  • Harriet de Wit
  • K. Luan Phan
Biological Psychiatry - Short communication

DOI: 10.1007/s00702-011-0747-x

Cite this article as:
Rabinak, C.A., Sripada, C.S., Angstadt, M. et al. J Neural Transm (2012) 119: 701. doi:10.1007/s00702-011-0747-x

Abstract

Cannabinoids affect positive and negative affective experience and emotional perception, possibly by modulating limbic brain reactivity. In this double-blind crossover, placebo-controlled functional magnetic resonance imaging study in humans, an acute oral dose of ∆9-tetrahydrocannabinol (THC) attenuated subgenual anterior cingulate cortex (sgACC) reactivity during the induction of negative affect. This observation extends prior findings implicating a cortico-limbic, emotion-related central mechanism underlying cannabinoid function.

Keywords

CannabinoidAmygdalaSubgenual anterior cingulateEmotionfMRI

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Christine A. Rabinak
    • 1
    • 3
  • Chandra Sekhar Sripada
    • 1
  • Mike Angstadt
    • 1
  • Harriet de Wit
    • 4
  • K. Luan Phan
    • 1
    • 2
    • 3
  1. 1.Department of PsychiatryUniversity of MichiganAnn ArborUSA
  2. 2.Neuroscience ProgramUniversity of MichiganAnn ArborUSA
  3. 3.Mental Health ServiceVeterans Affairs Ann Arbor Healthcare SystemAnn ArborUSA
  4. 4.Department of Psychiatry and Behavioral NeuroscienceUniversity of ChicagoChicagoUSA