, Volume 118, Issue 8, p 1177
Date: 24 Jul 2011

Comment: should we diagnose MCI in Parkinson disease?

This is an excerpt from the content

Both Rektorova and Martinez-Horta, and Kulisevsky agree that Parkinson disease (PD) patients have frequent cognitive impairment already at disease onset, which progresses at a varying rate, terminating in dementia in a substantial number of patients. Cognitive deterioration in PD follows an indolent course, like that seen in other neurodegenerative diseases, and it is an arbitrary decision to term any section of this process as mild cognitive impairment (MCI), or by any other name. It will be difficult to justify a “starting point” of MCI (since deterioration preceded it even if not fulfilling criteria), and even the conversion to dementia is more complicated to define than in Alzheimer disease (AD), since activities of daily living are impaired in PD by the motor disability, as well as by apathy, depression, etc. which precludes a clear-cut determination as it applies, for example, to AD.

The term MCI has been coined to denote the predementia cognitive impairment stage of AD and has at