Journal of Neural Transmission

, Volume 118, Issue 11, pp 1547–1557

Valeriana officinalis ameliorates vacuous chewing movements induced by reserpine in rats

Authors

    • Departamento de Química, Programa de Pós-Graduação em Bioquímica ToxicológicaUniversidade Federal de Santa Maria
    • Centro de Ciências Naturais e Exatas, Programa de Pós-Graduação em Bioquímica Toxicológica
  • Roselei Fachinetto
    • Departamento de Fisiologia e Farmacologia, Programa de Pós-Graduação em Farmacologia, and Programa de Pós-Graduação em Bioquímica ToxicológicaUniversidade Federal de Santa Maria
    • Centro de Ciências Naturais e Exatas, Programa de Pós-Graduação em Bioquímica Toxicológica
  • Alessandro de Souza Prestes
    • Departamento de Química, Programa de Pós-Graduação em Bioquímica ToxicológicaUniversidade Federal de Santa Maria
  • Caroline Wagner
    • Departamento de Química, Programa de Pós-Graduação em Bioquímica ToxicológicaUniversidade Federal de Santa Maria
  • Jéssie Haigert Sudati
    • Departamento de Química, Programa de Pós-Graduação em Bioquímica ToxicológicaUniversidade Federal de Santa Maria
  • Aline Augusti Boligon
    • Departamento de Farmácia IndustrialUniversidade Federal de Santa Maria
  • Margareth Linde Athayde
    • Departamento de Farmácia IndustrialUniversidade Federal de Santa Maria
  • Vera Maria Morsch
    • Departamento de Química, Programa de Pós-Graduação em Bioquímica ToxicológicaUniversidade Federal de Santa Maria
    • Departamento de Química, Programa de Pós-Graduação em Bioquímica ToxicológicaUniversidade Federal de Santa Maria
    • Abdus Salam International Centre for Theoretical Physics
    • Centro de Ciências Naturais e Exatas, Programa de Pós-Graduação em Bioquímica Toxicológica
Basic Neurosciences, Genetics and Immunology - Original Article

DOI: 10.1007/s00702-011-0640-7

Cite this article as:
Pereira, R.P., Fachinetto, R., de Souza Prestes, A. et al. J Neural Transm (2011) 118: 1547. doi:10.1007/s00702-011-0640-7

Abstract

Oral movements are associated with important neuropathologies as Parkinson’s disease and tardive dyskinesia. However, until this time, there has been no known efficacious treatment, without side effects, for these disorders. Thus, the aim of the present study was to investigate the possible preventive effects of V. officinalis, a phytotherapic that has GABAergic and antioxidant properties, in vacuous chewing movements (VCMs) induced by reserpine in rats. Adult male rats were treated with reserpine (1 mg/kg, s.c.) and/or with V. officinalis (in the drinking water, starting 15 days before the administration of the reserpine). VCMs, locomotor activity and oxidative stress measurements were evaluated. Furthermore, we carried out the identification of valeric acid and gallic acid by HPLC in the V. officinalis tincture. Our findings demonstrated that reserpine caused a marked increase on VCMs and the co-treatment with V. officinalis was able to reduce the intensity of VCM. Reserpine did not induce oxidative stress in cerebral structures (cortex, hippocampus, striatum and substantia nigra). However, a significant positive correlation between DCF-oxidation (an estimation of oxidative stress) in the cortex and VCMs (p < 0.05) was observed. Moreover, a negative correlation between Na+K+-ATPase activity in substantia nigra and the number of VCMs was observed (p < 0.05). In conclusion, V. officinalis had behavioral protective effect against reserpine-induced VCMs in rats; however, the exact mechanisms that contributed to this effect have not been completely understood.

Keywords

Oral dyskinesiaParkinson’s diseaseReserpineVacuous chewing movementsValeriana officinalis

Abbreviations

Tardive dyskinesia

TD

Parkinson’s disease

PD

Vacuous chewing movements

VCMs

Orofacial dyskinesia

OD

Monoaminoxidase

MAO

Valeriana officinalis

V. officinalis

Reactive oxygen species

ROS

2′,7′-Dichlorodihydrofluorescein diacetate

DCFH-DA

Thiobarbituric acid reactive substances

TBARS

Copyright information

© Springer-Verlag 2011