Basic Neurosciences, Genetics and Immunology - Original Article

Journal of Neural Transmission

, Volume 118, Issue 11, pp 1547-1557

First online:

Valeriana officinalis ameliorates vacuous chewing movements induced by reserpine in rats

  • Romaiana Picada PereiraAffiliated withDepartamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa MariaCentro de Ciências Naturais e Exatas, Programa de Pós-Graduação em Bioquímica Toxicológica Email author 
  • , Roselei FachinettoAffiliated withDepartamento de Fisiologia e Farmacologia, Programa de Pós-Graduação em Farmacologia, and Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa MariaCentro de Ciências Naturais e Exatas, Programa de Pós-Graduação em Bioquímica Toxicológica
  • , Alessandro de Souza PrestesAffiliated withDepartamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria
  • , Caroline WagnerAffiliated withDepartamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria
  • , Jéssie Haigert SudatiAffiliated withDepartamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria
  • , Aline Augusti BoligonAffiliated withDepartamento de Farmácia Industrial, Universidade Federal de Santa Maria
  • , Margareth Linde AthaydeAffiliated withDepartamento de Farmácia Industrial, Universidade Federal de Santa Maria
  • , Vera Maria MorschAffiliated withDepartamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria
  • , João Batista Teixeira RochaAffiliated withDepartamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa MariaAbdus Salam International Centre for Theoretical PhysicsCentro de Ciências Naturais e Exatas, Programa de Pós-Graduação em Bioquímica Toxicológica Email author 

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Abstract

Oral movements are associated with important neuropathologies as Parkinson’s disease and tardive dyskinesia. However, until this time, there has been no known efficacious treatment, without side effects, for these disorders. Thus, the aim of the present study was to investigate the possible preventive effects of V. officinalis, a phytotherapic that has GABAergic and antioxidant properties, in vacuous chewing movements (VCMs) induced by reserpine in rats. Adult male rats were treated with reserpine (1 mg/kg, s.c.) and/or with V. officinalis (in the drinking water, starting 15 days before the administration of the reserpine). VCMs, locomotor activity and oxidative stress measurements were evaluated. Furthermore, we carried out the identification of valeric acid and gallic acid by HPLC in the V. officinalis tincture. Our findings demonstrated that reserpine caused a marked increase on VCMs and the co-treatment with V. officinalis was able to reduce the intensity of VCM. Reserpine did not induce oxidative stress in cerebral structures (cortex, hippocampus, striatum and substantia nigra). However, a significant positive correlation between DCF-oxidation (an estimation of oxidative stress) in the cortex and VCMs (p < 0.05) was observed. Moreover, a negative correlation between Na+K+-ATPase activity in substantia nigra and the number of VCMs was observed (p < 0.05). In conclusion, V. officinalis had behavioral protective effect against reserpine-induced VCMs in rats; however, the exact mechanisms that contributed to this effect have not been completely understood.

Keywords

Oral dyskinesia Parkinson’s disease Reserpine Vacuous chewing movements Valeriana officinalis