Journal of Neural Transmission

, Volume 118, Issue 10, pp 1487–1495

Targeting of the pedunculopontine nucleus by an MRI-guided approach: a cadaver study

  • Ludvic Zrinzo
  • Laurence V. Zrinzo
  • Luke A. Massey
  • John Thornton
  • Harold G. Parkes
  • Mark White
  • Tarek A. Yousry
  • Catherine Strand
  • Tamas Revesz
  • Patricia Limousin
  • Marwan I. Hariz
  • Janice L. Holton
Basic Neurosciences, Genetics and Immunology - Original Article

DOI: 10.1007/s00702-011-0639-0

Cite this article as:
Zrinzo, L., Zrinzo, L.V., Massey, L.A. et al. J Neural Transm (2011) 118: 1487. doi:10.1007/s00702-011-0639-0

Abstract

Laboratory evidence suggests that the pedunculopontine nucleus (PPN) plays a central role in the initiation and maintenance of gait. Translational research has led to reports on deep brain stimulation (DBS) of the rostral brainstem in parkinsonian patients. However, initial clinical results appear to be rather variable. Possible factors include patient selection and the wide variability in anatomical location of implanted electrodes. Clinical studies on PPN DBS efficacy would, therefore, benefit from an accurate and reproducible method of stereotactic localization of the nucleus. The present study evaluates the anatomical accuracy of a specific protocol for MRI-guided stereotactic targeting of the PPN in a human cadaver. Imaging at 1.5 and 9.4 T confirmed electrode location in the intended region as defined anatomically by the surrounding fiber tracts. The spatial relations of each electrode track to the nucleus were explored by subsequent histological examination. This confirmed that the neuropil surrounding each electrode track contained scattered large neurons morphologically consistent with those of the subnucleus dissipatus and compactus of the PPN. The results support the accuracy of the described specific MR imaging protocol.

Keywords

Pedunculopontine nucleusMRIStereotacticDeep brain stimulation

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Ludvic Zrinzo
    • 1
    • 2
  • Laurence V. Zrinzo
    • 3
  • Luke A. Massey
    • 4
  • John Thornton
    • 5
    • 6
  • Harold G. Parkes
    • 6
    • 7
  • Mark White
    • 5
  • Tarek A. Yousry
    • 5
  • Catherine Strand
    • 8
  • Tamas Revesz
    • 8
  • Patricia Limousin
    • 1
  • Marwan I. Hariz
    • 1
    • 9
  • Janice L. Holton
    • 8
  1. 1.Unit of Functional NeurosurgeryBox 146, Institute of Neurology and National Hospital for Neurology and NeurosurgeryLondonUK
  2. 2.Victor Horsley Department of NeurosurgeryNational Hospital for Neurology and NeurosurgeryLondonUK
  3. 3.Department of Anatomy, Genetics and Cell BiologyUniversity of MaltaMsidaMalta
  4. 4.Sara Koe PSP Research Centre, UCL Institute of NeurologyLondonUK
  5. 5.Lysholm Department of NeuroradiologyUCL Institute of Neurology, National Hospital for Neurology and NeurosurgeryLondonUK
  6. 6.Department of Brain Repair and RehabilitationUCL Institute of Neurology, University College LondonLondonUK
  7. 7.Department of NeuroinflammationUCL Institute of Neurology, University College LondonLondonUK
  8. 8.Queen Square Brain Bank, Department of Molecular NeuroscienceUCL Institute of NeurologyLondonUK
  9. 9.Department of Clinical NeuroscienceUmeå UniversityUmeåSweden