Journal of Neural Transmission

, Volume 118, Issue 5, pp 683–689

TAR-DNA binding protein-43 and alterations in the hippocampus

  • Tuomas Rauramaa
  • Maria Pikkarainen
  • Elisabet Englund
  • Paul G. Ince
  • Kurt Jellinger
  • Anders Paetau
  • Irina Alafuzoff
Dementias - Original Article

DOI: 10.1007/s00702-010-0574-5

Cite this article as:
Rauramaa, T., Pikkarainen, M., Englund, E. et al. J Neural Transm (2011) 118: 683. doi:10.1007/s00702-010-0574-5

Abstract

Immunocytochemistry for transactive response binding protein-43 (TDP43) was assessed in the granular cell layer of the dentate gyrus in 250 cases displaying hippocampal pathology identified by haematoxylin–eosin staining. 18%, nearly one in five displayed TDP43 immunoreactive pathology in the granular cell layer of hippocampus. This percentage increased to 43% when only subjects with hippocampal pathology other than vascular in origin were included. When only subjects with severe Alzheimer’s disease-related pathology were included, 42% displayed TDP43-immunoreactive pathology, increasing to 60% when concomitant Alzheimer’s disease and α-synuclein pathology were present. Within this setting, TDP43-immunoreactive pathology was observed to be present in 6% of subjects with hippocampal pathology but without any cognitive impairment. Our findings justify assessment of TDP43 pathology in every case where a pathological alteration is observed in the hippocampus using a routine stain.

Keywords

TAR-DNA binding protein-43Hyperphosphorylated-τp62ImmunohistochemistryPost-mortemHippocampal alterations

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Tuomas Rauramaa
    • 1
    • 2
  • Maria Pikkarainen
    • 3
  • Elisabet Englund
    • 4
  • Paul G. Ince
    • 5
  • Kurt Jellinger
    • 6
  • Anders Paetau
    • 7
  • Irina Alafuzoff
    • 1
    • 3
    • 8
  1. 1.Department of PathologyKuopio University HospitalKuopioFinland
  2. 2.Institute of Clinical Medicine, Unit of PathologyUniversity of Eastern FinlandKuopioFinland
  3. 3.Institute of Clinical Medicine, Unit of Neurology, Section of NeuropathologyUniversity of Eastern FinlandKuopioFinland
  4. 4.Department of PathologyUniversity HospitalLundSweden
  5. 5.Department of NeurosciencesUniversity of SheffieldSheffieldUK
  6. 6.Institute of Clinical NeurobiologyViennaAustria
  7. 7.Department of PathologyUniversity of HelsinkiHelsinkiFinland
  8. 8.Department of Genetics and Pathology, Rudbeck LaboratoryUppsala University, Uppsala University HospitalUppsalaSweden