Journal of Neural Transmission

, Volume 118, Issue 4, pp 549–553

Micrographia induced by pallidal DBS for segmental dystonia: a subtle sign of hypokinesia?

Authors

    • Department of Neurology, Universitaetsmedizin Mannheim, UMMUniversity of Heidelberg
  • Hans-Holger Capelle
    • Department of NeurosurgeryMedical School Hannover, MHH
  • Hansjoerg Baezner
    • Department of Neurology, Universitaetsmedizin Mannheim, UMMUniversity of Heidelberg
  • Thomas M. Kinfe
    • Department of NeurosurgeryMedical School Hannover, MHH
  • Michael G. Hennerici
    • Department of Neurology, Universitaetsmedizin Mannheim, UMMUniversity of Heidelberg
  • Joachim K. Krauss
    • Department of NeurosurgeryMedical School Hannover, MHH
Movement Disorders - Short Communication

DOI: 10.1007/s00702-010-0544-y

Cite this article as:
Blahak, C., Capelle, H., Baezner, H. et al. J Neural Transm (2011) 118: 549. doi:10.1007/s00702-010-0544-y

Abstract

Recently parkinsonism has been reported as a rare side effect of globus pallidus internus (GPi) deep brain stimulation (DBS) for dystonia. In the present systematic prospective study in 11 patients with segmental dystonia not affecting distal arm function, we could demonstrate significant changes in handwriting characterized by mild micrographia following GPi-DBS. We propose that this finding reflects GPi-DBS-induced disturbances of basal ganglia function in terms of a mild hypokinetic syndrome, as a result of outflow alterations in pallido-thalamo-cortical pathways.

Keywords

DystoniaDeep brain stimulationGlobus pallidus internusMicrographiaHypokinesia

Copyright information

© Springer-Verlag 2011