Micrographia induced by pallidal DBS for segmental dystonia: a subtle sign of hypokinesia?
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Recently parkinsonism has been reported as a rare side effect of globus pallidus internus (GPi) deep brain stimulation (DBS) for dystonia. In the present systematic prospective study in 11 patients with segmental dystonia not affecting distal arm function, we could demonstrate significant changes in handwriting characterized by mild micrographia following GPi-DBS. We propose that this finding reflects GPi-DBS-induced disturbances of basal ganglia function in terms of a mild hypokinetic syndrome, as a result of outflow alterations in pallido-thalamo-cortical pathways.
- Micrographia induced by pallidal DBS for segmental dystonia: a subtle sign of hypokinesia?
Journal of Neural Transmission
Volume 118, Issue 4 , pp 549-553
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- Springer Vienna
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- Deep brain stimulation
- Globus pallidus internus
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- Author Affiliations
- 1. Department of Neurology, Universitaetsmedizin Mannheim, UMM, University of Heidelberg, Theodor-Kutzer Ufer 1-3, 68167, Mannheim, Germany
- 2. Department of Neurosurgery, Medical School Hannover, MHH, Hannover, Germany