Journal of Neural Transmission

, Volume 117, Issue 12, pp 1371–1376

Association of polymorphisms in genes involved in the dopaminergic pathway with blood pressure and uric acid levels in Chinese females

  • Ting-Kuang Yeh
  • Ting-Chi Yeh
  • Chi-Feng Weng
  • Bing-Fu Shih
  • Hsueh-Jen Tsao
  • Chien-Hua Hsiao
  • Fu-Tai Chuang
  • Chung-Yi Hu
  • Chun-Yen Chang
Basic Neurosciences, Genetics and Immunology - Original Article

DOI: 10.1007/s00702-010-0492-6

Cite this article as:
Yeh, TK., Yeh, TC., Weng, CF. et al. J Neural Transm (2010) 117: 1371. doi:10.1007/s00702-010-0492-6

Abstract

Since the high degree of heritability of physiological traits was demonstrated by twin and adoption studies, contemporary researchers in the fields of clinical medicine, behavioral science, and genetics have acknowledged the crucial role of genetic factors in human physiology. The study described herein explores the association between physiological parameters and the dopaminergic system using molecular genetic techniques. A total of 558 Taiwanese female volunteers, ranging from 16 to 17 years, were recruited. Single nucleotide polymorphisms in genes involved in the dopaminergic pathway were selected for analysis. Systolic blood pressure and diastolic blood pressure were associated significantly with the catechol-O-methyltransferase (COMT) Val158Met polymorphism and the dopamine β-hydroxylase (DBH) C1021T polymorphism. Furthermore, plasma uric acid was associated significantly with the COMT Val158Met polymorphism. Our study suggests the possible involvement of genetic polymorphisms in COMT and DBH in the regulation of blood pressure and plasma uric acid.

Keywords

Dopaminergic pathway Polymorphism Blood pressure Uric acid 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Ting-Kuang Yeh
    • 1
    • 2
  • Ting-Chi Yeh
    • 3
  • Chi-Feng Weng
    • 4
  • Bing-Fu Shih
    • 5
  • Hsueh-Jen Tsao
    • 1
  • Chien-Hua Hsiao
    • 1
  • Fu-Tai Chuang
    • 1
  • Chung-Yi Hu
    • 6
  • Chun-Yen Chang
    • 1
    • 2
  1. 1.Science Education Center and Graduate Institute of Science EducationNational Taiwan Normal UniversityTaipeiTaiwan, ROC
  2. 2.Department of Earth SciencesNational Taiwan Normal UniversityTaipeiTaiwan, ROC
  3. 3.Department of PediatricsMackay Memorial HospitalTaipeiTaiwan, ROC
  4. 4.Cardiac Care UnitCheng-Hsin General HospitalTaipeiTaiwan, ROC
  5. 5.Division of Nuclear MedicineMackay Memorial HospitalTaipeiTaiwan, ROC
  6. 6.Department of Clinical Laboratory Sciences and Medical Biotechnology, College of MedicineNational Taiwan UniversityTaipeiTaiwan, ROC

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