Journal of Neural Transmission

, Volume 117, Issue 12, pp 1353–1358

Molecular correlates of spontaneous activity in non-human primates

  • Amanda C. Mitchell
  • Georgina Aldridge
  • Shawn Kohler
  • Greg Stanton
  • Elinor Sullivan
  • Krassimira Garbett
  • Gabor Faludi
  • Károly Mirnics
  • Judy L. Cameron
  • William Greenough
Basic Neurosciences, Genetics and Immunology - Rapid Communication

DOI: 10.1007/s00702-010-0483-7

Cite this article as:
Mitchell, A.C., Aldridge, G., Kohler, S. et al. J Neural Transm (2010) 117: 1353. doi:10.1007/s00702-010-0483-7

Abstract

In our monkey model, cortical ARC and BDNF expressions were strongly correlated with spontaneous physical activity. The expressions of ARC and BDNF were inversely correlated with serum CRP levels, suggesting that CRP could be a putative peripheral marker of brain resiliency.

Keywords

Motor cortex Gene expression CRP Physical activity ARC BDNF 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Amanda C. Mitchell
    • 1
  • Georgina Aldridge
    • 3
  • Shawn Kohler
    • 3
  • Greg Stanton
    • 3
  • Elinor Sullivan
    • 4
  • Krassimira Garbett
    • 1
    • 2
  • Gabor Faludi
    • 6
  • Károly Mirnics
    • 1
    • 2
  • Judy L. Cameron
    • 4
    • 5
  • William Greenough
    • 3
  1. 1.Department of PsychiatryVanderbilt UniversityNashvilleUSA
  2. 2.Vanderbilt Kennedy Center for Research on Human DevelopmentVanderbilt UniversityNashvilleUSA
  3. 3.Beckman InstituteUniversity of Illinois at Urbana-ChampaignUrbanaUSA
  4. 4.Oregon National Primate Research CenterBeavertonUSA
  5. 5.Department of PsychiatryUniversity of PittsburghPittsburghUSA
  6. 6.Department of PsychiatrySemmelweis UniversityBudapestHungary