Parkinson’s disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans
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- Cornejo Castro, E.M., Waak, J., Weber, S.S. et al. J Neural Transm (2010) 117: 599. doi:10.1007/s00702-010-0397-4
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DJ-1 is a neuroprotective gene mutated in recessive Parkinson’s disease (PD). In addition to direct protective functions in neurons, DJ-1 regulates neuroinflammatory signaling in primary mouse brain astrocytes. To assess the influence of DJ-1 on innate immunity signaling in vivo, we have generated djr-1 knockout Caenorhabditis elegans. When grown on pathogenic gram-negative bacteria, djr-1−/− worms showed stronger phosphorylation of p38 mitogen-activated protein kinase (PMK-1) and hyper-induction of PMK-1 target genes. Thus, PD-associated DJ-1 contributes to regulation of innate immunity.