Journal of Neural Transmission

, Volume 116, Issue 11, pp 1503–1507

The particular relationship between Parkinson’s disease and malignancy: a focus on skin cancers

Basic Neurosciences, Genetics and Immunology - Review Article

DOI: 10.1007/s00702-009-0322-x

Cite this article as:
Inzelberg, R. & Israeli-Korn, S.D. J Neural Transm (2009) 116: 1503. doi:10.1007/s00702-009-0322-x


Although the risk for most cancers appears to be relatively low in patients with Parkinson’s disease (PD), skin cancers and melanomas occur more frequently in the PD population as compared to controls. This article summarizes the findings of cohort studies on skin cancer in Parkinson’s disease. Given that melanoma may precede use of l-dopa, the increased risk of melanoma for PD patients cannot be attributed to l-dopa. On the basis of these observations it may be reasonable to recommend that all patients with PD, whether treated with l-dopa or not, should undergo regular dermatological screening for neoplastic or pre-neoplastic skin lesions, especially melanoma.


Parkinson’s diseaseCancerMelanomaSkin cancer

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of Neurology, The Sagol Neuroscience CenterSheba Medical CenterTel HashomerIsrael
  2. 2.Tel Aviv UniversityTel AvivIsrael