Journal of Neural Transmission

, 117:1

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

Authors

  • Michele Guescini
    • Department of Biomolecular SciencesUniversity of Urbino ‘Carlo Bo’
  • Susanna Genedani
    • Department Biomedical SciencesUniversity of Modena and Reggio Emilia
  • Vilberto Stocchi
    • Department of Biomolecular SciencesUniversity of Urbino ‘Carlo Bo’
    • Department Biomedical SciencesUniversity of Modena and Reggio Emilia
    • IRCCS Lido
Basic Neurosciences, Genetics and Immunology - Rapid Communication

DOI: 10.1007/s00702-009-0288-8

Cite this article as:
Guescini, M., Genedani, S., Stocchi, V. et al. J Neural Transm (2010) 117: 1. doi:10.1007/s00702-009-0288-8

Abstract

Cells can exchange information not only by means of chemical and/or electrical signals, but also via microvesicles released into the intercellular space. The present paper, for the first time, provides evidence that Glioblastoma and Astrocyte cells release microvesicles, which carry mitochondrial DNA (mtDNA). These microvesicles have been characterised as exosomes in view of the presence of some protein markers of exosomes, such as Tsg101, CD9 and Alix. Thus, the important finding has been obtained that bonafide exosomes, constitutively released by Glioblastoma cells and Astrocytes, can carry mtDNA, which can be, therefore, transferred between cells. This datum may help the understanding of some diseases due to mitochondrial alterations.

Keywords

Glioblastoma cellsAstrocytesMitochondrial DNAExosomesIntercellular communication

Copyright information

© Springer-Verlag 2009