Journal of Neural Transmission

, Volume 116, Issue 11, pp 1443–1449

Neuroprotection and neurogeneration in MS and its animal model EAE effected by glatiramer acetate

Basic Neurosciences, Genetics and Immunology - Review Article

DOI: 10.1007/s00702-009-0272-3

Cite this article as:
Arnon, R. & Aharoni, R. J Neural Transm (2009) 116: 1443. doi:10.1007/s00702-009-0272-3


It is by now established that multiple sclerosis (MS) is not simply an autoimmune disease and that in addition to inflammation and demyelination, axonal injury and neuronal loss underlie the accumulation of disability and the disease progression. Specific treatment strategies should thus target the injury sites at the central nervous system (CNS) to interfere with both neuroinflammation and neurodegeneration. Glatiramer acetate (GA Copaxone®, Copolymer 1), an approved drug for the treatment of multiple sclerosis, was shown earlier to act as an anti-inflammatory and immunomodulatory agent. In this mini-review its effect on neuroprotection, neurogenesis and on the remyelination process is delineated in the EAE model. The plausible mechanism underlying this multifactorial effect is the induction of GA-reactive T-cells in the periphery and their infiltration into the CNS, where they release immunomodulatory cytokines and neurotrophic factors in the injury site, suggesting a direct linkage to its therapeutic effect in both EAE and MS.


Neuroprotection Neurogenesis Neurotrophic factors (NTs) Multiple sclerosis (MS) Experimental autoimmune encephalomyelitis (EAE) Glatiramer acetate (GA) 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.The Department of ImmunologyThe Weizmann Institute of ScienceRehovotIsrael

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