Journal of Neural Transmission

, Volume 116, Issue 7, pp 897–903

Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly

  • Heike Kölsch
  • Michael Wagner
  • Andras Bilkei-Gorzó
  • Mohammad Reza Toliat
  • Michael Pentzek
  • Angela Fuchs
  • Hanna Kaduszkiewicz
  • Hendrik van den Bussche
  • Steffi G. Riedel-Heller
  • Matthias C. Angermeyer
  • Siegfried Weyerer
  • Jochen Werle
  • Horst Bickel
  • Edelgard Mösch
  • Birgitt Wiese
  • Moritz Daerr
  • Frank Jessen
  • Wolfgang Maier
  • Martin Dichgans
Basic Neurosciences, Genetics and Immunology - Original Article

DOI: 10.1007/s00702-009-0238-5

Cite this article as:
Kölsch, H., Wagner, M., Bilkei-Gorzó, A. et al. J Neural Transm (2009) 116: 897. doi:10.1007/s00702-009-0238-5

Abstract

Cognitive functions show large variation in elderly people and are substantially heritable. Animal studies revealed that dynorphins influence cognition and memory, especially in aged animals. Thus, we tested the effect of four SNPs (rs7272891, rs1997794, rs2235751 and rs910080) and the VNTR promoter polymorphism in the prodynorphin gene (PDYN) on episodic memory and verbal fluency in a large (n = 1619) sample of elderly people (mean age: 80 ± 3.39 years; range 75–90 years) recruited through the German study on ageing, cognition and dementia in primary care patients (AgeCoDe). We found that carriers of the minor alleles of rs1997794 (P < 0.002) and rs910080 (P < 0.005) presented with higher episodic memory scores than homozygote carriers of the major allele. Also, a three marker haplotype including these two SNPs and rs2235751 was associated with better episodic memory scores. Verbal fluency scores were non-significantly better in carriers of these respective alleles. Thus, our results suggest a role of PDYN gene variations in determining memory function also in elderly humans.

Keywords

PDYN Episodic memory Verbal fluency Aging Genetic association 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Heike Kölsch
    • 1
  • Michael Wagner
    • 1
  • Andras Bilkei-Gorzó
    • 2
  • Mohammad Reza Toliat
    • 3
  • Michael Pentzek
    • 4
  • Angela Fuchs
    • 4
  • Hanna Kaduszkiewicz
    • 5
  • Hendrik van den Bussche
    • 5
  • Steffi G. Riedel-Heller
    • 6
  • Matthias C. Angermeyer
    • 6
  • Siegfried Weyerer
    • 7
  • Jochen Werle
    • 7
  • Horst Bickel
    • 8
  • Edelgard Mösch
    • 8
  • Birgitt Wiese
    • 9
  • Moritz Daerr
    • 1
  • Frank Jessen
    • 1
  • Wolfgang Maier
    • 1
  • Martin Dichgans
    • 10
  1. 1.Department of PsychiatryUniversity of BonnBonnGermany
  2. 2.Institute of Molecular PsychiatryUniversity of BonnBonnGermany
  3. 3.Cologne Center for GenomicsUniversity of CologneCologneGermany
  4. 4.Department of General PracticeDüsseldorf University Medical Center DüsseldorfGermany
  5. 5.Institute of Primary Medical CareUniversity Medical Center Hamburg-Eppendorf HamburgGermany
  6. 6.Department of PsychiatryUniversity of LeipzigLeipzigGermany
  7. 7.Central Institute of Mental HealthMannheimGermany
  8. 8.Department of PsychiatryTechnical University of MunichMunichGermany
  9. 9.Institute for BiometricsHannover Medical SchoolHannover Germany
  10. 10.Department of NeurologyLudwig-Maximilian-University MunichMunichGermany

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