Journal of Neural Transmission

, Volume 116, Issue 5, pp 599–605

A single-nucleotide polymorphism of the osteopontin gene may contribute to a susceptibility to Lewy body disease

  • Walter Maetzler
  • Joan Michelis
  • Juergen Tomiuk
  • Arthur Melms
  • Clemens Becker
  • Thomas Gasser
  • Claudia Schulte
  • Daniela Berg
Dementias - Original Article

DOI: 10.1007/s00702-009-0209-x

Cite this article as:
Maetzler, W., Michelis, J., Tomiuk, J. et al. J Neural Transm (2009) 116: 599. doi:10.1007/s00702-009-0209-x

Abstract

In Lewy body disease, inflammation is discussed to be involved in the pathophysiological cascade. Osteopontin (OPN) is a multifunctional molecule, which is increased in inflammatory states. Here, we analyzed the allele frequency of two SNPs of the OPN gene, serum, and CSF OPN levels in Lewy body disease patients and controls. In accordance with our previous findings, we detected increased serum (P = 0.006) and CSF OPN levels (P = 0.0003) in the Lewy body disease cohort, compared to non-Lewy body disease subjects. The genotypic variation of SNP−66 was associated with the occurrence of Lewy body disease (odds ratio: 2.64, 95% CI 1.07–6.54, unadjusted P = 0.036). SNP+1239 was not related to Lewy body disease prevalence (odds ratio 1.61, 95% CI 0.66–3.91, P = 0.29). Genotype prevalence and OPN levels were not significantly related. These findings suggest that OPN is associated with the occurrence of Lewy body disease and SNP−66 may be a susceptibility factor.

Keywords

Age Aging Cerebrospinal fluid Immune response Serum 

Supplementary material

702_2009_209_MOESM1_ESM.pdf (16 kb)
Supplementary material 1 (PDF 15 kb)

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Walter Maetzler
    • 1
    • 2
  • Joan Michelis
    • 1
  • Juergen Tomiuk
    • 3
  • Arthur Melms
    • 4
  • Clemens Becker
    • 2
  • Thomas Gasser
    • 1
  • Claudia Schulte
    • 1
  • Daniela Berg
    • 1
  1. 1.Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain ResearchUniversity of TuebingenTübingenGermany
  2. 2.Department of Geriatric RehabilitationRobert-Bosch-HospitalStuttgartGermany
  3. 3.Department of Medical GeneticsUniversity of TuebingenTübingenGermany
  4. 4.Department of General NeurologyUniversity of TuebingenTübingenGermany