Journal of Neural Transmission

, Volume 116, Issue 4, pp 437–441

Experience with long-term treatment with albumin-supplemented botulinum toxin type A

Authors

    • Department of Neurology and Clinical NeurophysiologyMedical School Hannover
    • Department of NeuropsychologyOtto-von-Guericke-University
  • Katja Kollewe
    • Department of Neurology and Clinical NeurophysiologyMedical School Hannover
  • Maresa Wegener
    • Department of Neurology and Clinical NeurophysiologyMedical School Hannover
  • Hans Bigalke
    • Institute of ToxicologyMedical School Hannover
  • Reinhard Dengler
    • Department of Neurology and Clinical NeurophysiologyMedical School Hannover
Basic Neurosciences, Genetics and Immunology - Original Article

DOI: 10.1007/s00702-009-0200-6

Cite this article as:
Mohammadi, B., Kollewe, K., Wegener, M. et al. J Neural Transm (2009) 116: 437. doi:10.1007/s00702-009-0200-6

Abstract

In earlier studies, we have demonstrated the efficacy of albumin-supplemented botulinum toxin type A (ASBTA) in principle. Here, we present long-term data from 106 patients who received ASTBA over 5–10 years for the treatment of cervical dystonia, blepharospasm and hemifacial spasm. Vials of Dysport® were diluted in 0.1% albumin solution to a concentration of 25 units/ml. Overall patients and indications, the mean latency to response was 7.1 ± 2.2 days, the mean duration of response was 12.3 ± 3.1 weeks and the mean global clinical improvement (scale 0–3) was 2.6 ± 0.2. Only one patient had neutralizing antibodies against BoNT-A. Side effects were less frequent than known for conventional BoNT-A and generally mild. These findings were confirmed by analysis of data of 71 patients who have been reconverted from ASBTA to conventional dilutions of Dysport® or Botox®. We conclude that long-term treatment with ASBTA is effective, safe and help to reduce costs.

Keywords

Botulinum toxin type ACervical dystoniaBlepharospasmHemifacial spasmLow-dose therapy

Copyright information

© Springer-Verlag 2009