Journal of Neural Transmission

, Volume 116, Issue 5, pp 623–629

Differentiating attention-deficit/hyperactivity disorder inattentive and combined types: a 1H-magnetic resonance spectroscopy study of fronto-striato-thalamic regions

  • Pedro E. M. S. Ferreira
  • André Palmini
  • Claiton H. D. Bau
  • Eugenio Horacio Grevet
  • João Rubião Hoefel
  • Luis Augusto Rohde
  • Maurício Anés
  • Eloisa Elena Ferreira
  • Paulo Belmonte-de-Abreu
Biological Child and Adolescent Psychiatry - Original Article

DOI: 10.1007/s00702-009-0191-3

Cite this article as:
Ferreira, P.E.M.S., Palmini, A., Bau, C.H.D. et al. J Neural Transm (2009) 116: 623. doi:10.1007/s00702-009-0191-3

Abstract

Despite the implication of fronto-striatal circuits in attention-deficit/hyperactivity disorder (ADHD), there is a lack of information on the role of these regions, especially the thalamus, in the heterogeneity of ADHD. We assessed the 1H-magnetic resonance spectroscopy profile in ventromedial prefrontal cortex (VMPFC)-thalamic-striatal regions bilaterally in three groups of subjects (age range 18–24 years old): ADHD inattentive type (ADHD-I; n = 9), ADHD combined type (ADHD-C; n = 10) and non-ADHD controls (n = 12). The peaks of N-acetylaspartate, Choline (Cho), myo-inositol (mI), creatine (Cr) and glutamate-glutamine-GABA (Glx) to Cr were calculated. Subjects with ADHD-C showed lower mI/Cr ratio in the right VMPFC than controls, higher Cho/Cr ratio in the left thalamus-pulvinar than the ADHD-I group and higher Glx/Cr ratio in left putamen than individuals with ADHD-I and controls. This metabolic profile suggests a disruption of fronto-striato-thalamic structures in the ADHD-C as a result of lower neuronal energetic metabolism.

Keywords

Attention-deficit/hyperactivity disorderNeuroimagingSpectroscopyInattentionHyperactivityDiagnosis

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Pedro E. M. S. Ferreira
    • 1
  • André Palmini
    • 1
  • Claiton H. D. Bau
    • 2
  • Eugenio Horacio Grevet
    • 3
  • João Rubião Hoefel
    • 4
  • Luis Augusto Rohde
    • 3
  • Maurício Anés
    • 4
  • Eloisa Elena Ferreira
    • 1
  • Paulo Belmonte-de-Abreu
    • 3
  1. 1.Graduate Program in Neurosciences, and Neurology and Psychiatry Services, Serviço de Psiquiatria do Hospital São Lucas da PUCRSHospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul (HSL-PUCRS)Porto AlegreBrazil
  2. 2.Department of GeneticsUniversidade Federal do Rio Grande do Sul (UFRGS)Porto AlegreBrazil
  3. 3.Department of PsychiatryUniversidade Federal do Rio Grande do Sul (UFRGS)Porto AlegreBrazil
  4. 4.Center for Diagnostic Imaging (CDI-HSL-PUCRS)Porto AlegreBrazil