Journal of Neural Transmission

, Volume 115, Issue 2, pp 335–339

No increase in long-term risk for nicotine use disorders after treatment with methylphenidate in children with attention-deficit/hyperactivity disorder (ADHD): evidence from a non-randomised retrospective study


DOI: 10.1007/s00702-008-0872-3

Cite this article as:
Huss, M., Poustka, F., Lehmkuhl, G. et al. J Neural Transm (2008) 115: 335. doi:10.1007/s00702-008-0872-3


Objective. To evaluate long-term effects of methylphenidate (MPH) treatment in ADHD children on the development of nicotine use disorders (SUD-N).

Methods. Multisite retrospective non-randomised longitudinal study with 215 ADHD children (diagnosis at 9.2 years of age; reassessment for SUD-N at 21.9 years of age) strictly parallel allocated to MPH treated (n = 106) and drug naive (n = 109) children.

Results. There was no difference between the groups with respect to frequency (84% MPH; 89% non-MPH; χ2 = 1.6; p = 0.21) and age of onset for first cigarette smoking (log rank 1.68; p = 0.19). Continuous smoking was reached by 51% (MPH) and 61% (non-MPH) of the patients. Survival analyses revealed a small and nominally significant delay in age of onset for continuous smoking in the MPH-group (log rank = 3.85; p = 0.049). Nicotine dependency was reached by 20% (MPH) and 27% (non-MPH). Age of onset does not differ between groups (log rank = 2.24; p = 0.13).

Discussion. Limited evidence due to the non-randomised nature of the study is given that MPH does not induce SUD-N. The data suggests there may be a beneficial effect of MPH on delay of onset for continuous nicotine consumption in ADHD patients.

Keywords: Methylphenidate; attention-deficit/hyperactivity disorder; (ADHD) – substance use disorder; nicotine dependency; long-term outcome 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Head of Department for Child and Adolescent PsychiatryJohannes Gutenberg-UniversityMainzGermany
  2. 2.Child and Adolescent PsychiatryGoethe University FrankfurtFrankfurt a.M.Germany
  3. 3.Child and Adolescent PsychiatryUniversity of CologneCologneGermany
  4. 4.Child and Adolescent PsychiatryCharité University Medicine BerlinBerlinGermany

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