Parkinson's Disease and Allied Conditions - Original Article

Journal of Neural Transmission

, Volume 116, Issue 2, pp 193-202

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

MEG resting state functional connectivity in Parkinson’s disease related dementia

  • J. L. W. BosboomAffiliated withDepartment of Neurology, VU University Medical Center Email author 
  • , D. StoffersAffiliated withDepartment of Neurology, VU University Medical CenterDepartment of Clinical Neuropsychology, VU University
  • , E. Ch. WoltersAffiliated withDepartment of Neurology, VU University Medical Center
  • , C. J. StamAffiliated withDepartment of Clinical Neurophysiology, VU University Medical Center
  • , H. W. BerendseAffiliated withDepartment of Neurology, VU University Medical Center


Parkinson’s disease (PD) related dementia (PDD) develops in up to 60% of patients, but the pathophysiology is far from being elucidated. Abnormalities of resting state functional connectivity have been reported in Alzheimer’s disease (AD). The present study was performed to determine whether PDD is likewise characterized by changes in resting state functional connectivity. MEG recordings were obtained in 13 demented and 13 non-demented PD patients. The synchronization likelihood (SL) was calculated within and between cortical areas in six frequency bands. Compared to non-demented PD, PDD was characterized by lower fronto-temporal SL in the alpha range, lower intertemporal SL in delta, theta and alpha1 bands as well as decreased centro-parietal gamma band synchronization. In addition, higher parieto-occipital synchronization in the alpha2 and beta bands was found in PDD. The observed changes in functional connectivity are reminiscent of changes in AD, and may reflect reduced cholinergic activity and/or loss of cortico-cortical anatomical connections in PDD.


Parkinson’s disease Dementia Magneto encephalography (MEG) Resting state Functional connectivity Synchronization likelihood