Journal of Neural Transmission

, 115:1621

Antidepressant-like activity of zinc: further behavioral and molecular evidence

  • Magdalena Sowa-Kućma
  • Beata Legutko
  • Bernadeta Szewczyk
  • Kinga Novak
  • Paweł Znojek
  • Ewa Poleszak
  • Mariusz Papp
  • Andrzej Pilc
  • Gabriel Nowak
Basic Neurosciences, Genetics and Immunology - Original Article

DOI: 10.1007/s00702-008-0115-7

Cite this article as:
Sowa-Kućma, M., Legutko, B., Szewczyk, B. et al. J Neural Transm (2008) 115: 1621. doi:10.1007/s00702-008-0115-7

Abstract

Zinc exhibits antidepressant-like activity in preclinical tests (the forced swim test and tail suspension test) and in olfactory bulbectomy and chronic unpredictable stress; two models of depression. Zinc also enhances the treatment of depression in humans. In the present study we evaluated the antidepressant activity of zinc in another model of depression—chronic mild stress (CMS) and the effect of zinc treatment on BDNF protein and the mRNA level. In CMS zinc hydroaspartate (10 mg/kg) exhibited a rapid (after 1 week of treatment) antidepressant-like effect. Chronic treatment with zinc induced a 17–39% increase in the BDNF mRNA and protein level in the hippocampus. These data indicate a rapidly acting antidepressant-like activity of zinc in CMS and the involvement of zinc in the regulation of BDNF.

Keywords

Zinc chronic mild stressBDNF depression

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Magdalena Sowa-Kućma
    • 1
  • Beata Legutko
    • 1
    • 2
  • Bernadeta Szewczyk
    • 1
  • Kinga Novak
    • 1
  • Paweł Znojek
    • 1
    • 3
  • Ewa Poleszak
    • 4
  • Mariusz Papp
    • 1
  • Andrzej Pilc
    • 1
    • 5
  • Gabriel Nowak
    • 1
    • 6
  1. 1.Institute of PharmacologyPolish Academy of SciencesKrakówPoland
  2. 2.Department of Psychiatry and Human BehaviorUniversity of Mississippi Medical CenterJacksonUSA
  3. 3.Northern Institute for Cancer Research, Medical SchoolUniversity of Newcastle upon TyneNewcastle upon TyneUK
  4. 4.Department of Pharmacology and PharmacodynamicsSkubiszewski Medical University of LublinLublinPoland
  5. 5.Institute of Public Health, Collegium MedicumJagiellonian UniversityKrakówPoland
  6. 6.Department of Cytobiology and HistochemistryCollegium Medicum, Jagiellonian UniversityKrakówPoland