Journal of Neural Transmission

, Volume 115, Issue 9, pp 1275–1277

LRRK2 Gly2385Arg mutation and clinical features in a Chinese population with early-onset Parkinson’s disease compared to late-onset patients

Authors

    • Department of Aged Care and RehabilitationBankstown-Lidcombe Hospital
    • Faculty of MedicineUniversity of New South Wales
  • Ping Wing Ng
    • Department of Medicine and GeriatricsUnited Christian Hospital
  • Vincent Mok
    • Neurology Division, Department of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong Kong
  • Jonas Yeung
    • Department of MedicineAHML Nethersole Hospital
  • Zhi Ming Fang
    • Cancer Care CentreSt George Hospital
  • Raymond Clarke
    • Cancer Care CentreSt George Hospital
  • Edward Leung
    • Department of Medicine and GeriatricsUnited Christian Hospital
  • Lawrence Wong
    • Neurology Division, Department of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong Kong
Basic Neurosciences, Genetics and Immunology - Short Communication

DOI: 10.1007/s00702-008-0065-0

Cite this article as:
Chan, D.K.Y., Ng, P.W., Mok, V. et al. J Neural Transm (2008) 115: 1275. doi:10.1007/s00702-008-0065-0

Abstract

The frequency of LRRK2 Gly2385Arg mutation in Hong Kong Chinese with early-onset (age ≤45 years) Parkinson’s disease was identified and compared with late-onset patients (age >50 years) and controls. The mutation prevalence were 8.8, 8.3, and 0% for early-onset, late-onset, and controls, respectively. The mean age of onset among LRRK2 G2385R carriers was 42.7 years old for early-onset compared to 74.3 for late-onset patients. LRRK2 G2385R mutation appears to be as prevalent among early-onset as late-onset patients.

Keywords

Early-onset Parkinson’s diseaseLRRK2 Gly2385Arg mutationChinese

Copyright information

© Springer-Verlag 2008