Journal of Neural Transmission

, Volume 115, Issue 9, pp 1321–1325

Investigation of the functional brain-derived neurotrophic factor gene variant Val66MET in migraine

Authors

    • Department of NeurologyUniversity of Würzburg
    • Department of NeurologySaarland University
    • Department of NeurologyUniversity of Münster
  • Andrea Herzog
    • Department of Psychiatry and PsychotherapyUniversity of Würzburg
  • Rainald Mössner
    • Department of Psychiatry and PsychotherapyUniversity of Würzburg
    • Department of Psychiatry and PsychotherapyUniversity of Bonn
  • Claudia Sommer
    • Department of NeurologyUniversity of Würzburg
Basic Neurosciences, Genetics and Immunology - Original Article

DOI: 10.1007/s00702-008-0056-1

Cite this article as:
Marziniak, M., Herzog, A., Mössner, R. et al. J Neural Transm (2008) 115: 1321. doi:10.1007/s00702-008-0056-1

Abstract

Experimental studies and investigations of the cerebrospinal fluid in migraineurs have suggested an involvement of brain-derived neurotrophic factor (BDNF) in migraine pathophysiology. In a case–control study approach, the functional Val66MET polymorphism (rs6265) of the BDNF gene was investigated in 265 migraine patients and 153 controls. Genotype and allele frequencies did not differ between healthy subjects and migraineurs. A subgroup analysis for the occurrence of aura or clinical characteristics, including the number of attacks, did not reveal a positive association for the investigated polymorphism. Our data argue against a role of this well characterized BDNF gene variant as a risk factor in migraine.

Keywords

Brain-derived neurotrophic factorPolymorphismMigraineCalcitonin-gene-related peptide

Copyright information

© Springer-Verlag 2008