Basic Neurosciences, Genetics and Immunology - Original Article

Journal of Neural Transmission

, Volume 115, Issue 9, pp 1321-1325

Investigation of the functional brain-derived neurotrophic factor gene variant Val66MET in migraine

  • Martin MarziniakAffiliated withDepartment of Neurology, University of WürzburgDepartment of Neurology, Saarland UniversityDepartment of Neurology, University of Münster Email author 
  • , Andrea HerzogAffiliated withDepartment of Psychiatry and Psychotherapy, University of Würzburg
  • , Rainald MössnerAffiliated withDepartment of Psychiatry and Psychotherapy, University of WürzburgDepartment of Psychiatry and Psychotherapy, University of Bonn
  • , Claudia SommerAffiliated withDepartment of Neurology, University of Würzburg

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Abstract

Experimental studies and investigations of the cerebrospinal fluid in migraineurs have suggested an involvement of brain-derived neurotrophic factor (BDNF) in migraine pathophysiology. In a case–control study approach, the functional Val66MET polymorphism (rs6265) of the BDNF gene was investigated in 265 migraine patients and 153 controls. Genotype and allele frequencies did not differ between healthy subjects and migraineurs. A subgroup analysis for the occurrence of aura or clinical characteristics, including the number of attacks, did not reveal a positive association for the investigated polymorphism. Our data argue against a role of this well characterized BDNF gene variant as a risk factor in migraine.

Keywords

Brain-derived neurotrophic factor Polymorphism Migraine Calcitonin-gene-related peptide