Biological Child and Adolescent Psychiatry - Short Communication

Journal of Neural Transmission

, Volume 115, Issue 6, pp 937-940

First online:

Serum levels of S100B are decreased in chronic starvation and normalize with weight gain

  • Kristian HoltkampAffiliated withDepartment of Child and Adolescent Psychiatry and Psychotherapy, RWTH Aachen UniversityDepartment of Child and Adolescent Psychiatry and Psychotherapy, RWTH Aachen University Email author 
  • , Katharina BührenAffiliated withDepartment of Child and Adolescent Psychiatry and Psychotherapy, RWTH Aachen University
  • , Gerald PonathAffiliated withDepartment of Psychiatry, School of Medicine, University of Münster
  • , Christoph von EiffAffiliated withInstitute of Medical Microbiology, School of Medicine, University of Münster
  • , Beate Herpertz-DahlmannAffiliated withDepartment of Child and Adolescent Psychiatry and Psychotherapy, RWTH Aachen University
  • , Johannes HebebrandAffiliated withDepartment of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg-Essen
  • , Matthias RothermundtAffiliated withDepartment of Psychiatry, School of Medicine, University of Münster

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Abstract

S100B protein is mainly synthesized in glial cells and modulates the balance between cell proliferation and differentiation in neurons and glial cells. However, S100B is not CNS-specific since its production was detected in numerous non-cerebral tissues e.g. adipocytes. In this study we investigated the influence of chronic fasting and subsequent weight gain on serum levels of S100B in patients with anorexia nervosa. We found that nutritional status was an important factor influencing serum levels of S100B.

Keywords

Eating disorder Fasting Starvation S100 Anorexia nervosa