The use of botulinum neurotoxin type A (BoNTA) in urology Article First Online: 06 March 2008 Received: 18 July 2007 Accepted: 08 November 2007 DOI:
Cite this article as: Apostolidis, A. & Fowler, C. J Neural Transm (2008) 115: 593. doi:10.1007/s00702-007-0862-x Summary
The use of Botulinum neurotoxin type A (BoNT/A) in the lower urinary tract was pioneered as early as 20 years ago with injections into the urethral sphincter reducing bladder voiding pressures, urethral pressures, and post-void residual urine. Over the past 9 years, the use of BoNT/A has revolutionised the treatment of intractable symptoms associated with the neurogenic or idiopathic overactive bladder, both in adults and children. The duration of clinical improvement is 6–11 months, is accompanied by significant amelioration of patients’ quality of life and repeat bladder treatments appear to have sustained effects. Despite evidence for an effect on the afferent pathways, its mode of action in the human bladder remains largely unknown. The use of BoNT/A has also expanded into the painful bladder syndrome and in benign prostatic diseases, with promising preliminary results.
This review aims to provide an insight of the use of BoNT/A in the lower urinary tract, addressing issues such as treatment outcomes and safety, mechanisms of action and potential for future research.
Keywords: Botulinum toxin; overactive bladder; detrusor overactivity; hyperreflexia; detrusor-sphincter dyssynergia; painful bladder; prostate
Correspondence: Apostolos Apostolidis, 2nd Department of Urology, Papageorgiou Hospital, Aristotle University of Thessaloniki, Ring Road, Nea Efkarpia, 56429 Thessaloniki, Greece
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