Executive control in obsessive-compulsive disorder: event-related potentials in a Go/Nogo task Authors
First Online: 05 July 2007 Received: 18 April 2007 Accepted: 14 June 2007 DOI:
Cite this article as: Ruchsow, M., Reuter, K., Hermle, L. et al. J Neural Transm (2007) 114: 1595. doi:10.1007/s00702-007-0779-4 Summary
Obsessive-compulsive disorder (OCD) has been related to a hyperactive cortico-striatal-pallidal-thalamic circuitry resulting clinically in an impaired inhibition of repetitive thoughts and behaviors. We examined thirteen patients with OCD and thirteen age-, sex-, and education matched healthy controls using event-related potentials (ERPs). Participants performed a hybrid flanker-Go/Nogo task while multichannel EEG was recorded. Our study focused on two ERP components: the Nogo-N2 and the Nogo-P3, which have been discussed in the context of response inhibition and response conflict. Artifact-free EEG-segments were used to compute ERPs on correct Go trials (button press) and correct Nogo trials (no button press), separately. Patients with OCD showed enhanced (more negative) Nogo-N2 amplitudes than controls, and a significant difference in amplitudes between Nogo-N2 and Go-N2 trials (more negative for Nogo trials) at central midline electrode positions. However, groups did not differ with regard to the Nogo-P3 and Go-P3. The present study replicates and extends previous findings of altered executive control processes in OCD patients.
Keywords: Obsessive-compulsive disorder (OCD); executive control processes; Nogo-N2; Nogo-P3 References Adler, CM, McDonough-Ryan, P, Sax, KW, Holland, SK, Arndt, S, Strakowski, SM 2000 fMRI of neuronal activation with symptom provocation in unmedicated patients with obsessive compulsive disorder J Psychiatr Res 34 317 324 PubMed CrossRef Anderson, V, Jacobs, R, Harvey, AS 2005 Prefrontal lesions and attentional skills in childhood J Int Neuropsychol Soc 11 817 831 PubMed APA (American Psychiatric Association) 1994Diagnostic and statistical manual of mental disorders (DSM-IV) American Psychiatric Association Washington, DC Bartholow, BD, Pearson, MA, Dickter, CL, Sher, KJ, Fabiani, M, Gratton, G 2005 Strategic control and medial frontal negativity: beyond errors and response conflict Psychophysiology 42 33 42 PubMed CrossRef Baxter, LRJ, Phelps, ME, Mazziotta, JC, Guze, BH, Schwartz, JM, Selin, CE 1987 Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls Arch Gen Psychiatry 44 211 218 PubMed Bruin, KJ, Wijers, AA 2002 Inhibition, response mode, and stimulus probability: a comparative event-related potential study Clin Neurophysiol 113 1172 1182 PubMed CrossRef Burle, B, Vidal, F, Bonnet, M 2004 Electroencephalographic nogo potentials in a no-movement context: the case of motor imagery in humans Neurosci Lett 360 77 80 PubMed CrossRef Carbonnell, L, Falkenstein, M 2006 Does the error negativity reflect the degree of response conflict? Brain Res 1095 124 130 PubMed CrossRef Donkers, FC, van Boxtel, GJ 2004 The N2 in go/no-go tasks reflects conflict monitoring not response inhibition Brain Cogn 56 165 176 PubMed Falkenstein, M, Hohnsbein, J, Hoormann, J, Blanke, L 1990 Effects of errors in choice reaction tasks on the ERP under focused and divided attention Brunia, C Gaillard, A Kok, A eds. Psychophysiological brain research Tilburg University Press Tilburg 192 195 Falkenstein, M, Hoormann, J, Hohnsbein, J 1999 ERP components in Go/Nogo tasks and their relation to inhibition Acta Psychol (Amst) 101 267 291 CrossRef Fitzgerald, KD, Welsh, RC, Gehring, WJ, Abelson, JL, Himle, JA, Liberzon, I, Taylor, SF 2005 Error-related hyperactivity of the anterior cingulate cortex in obsessive-compulsive disorder Biol Psychiatry 57 287 294 PubMed CrossRef Gehring, W, Himle, J, Nisenson, L 2000 Action monitoring dysfunction in obsessive-compulsive disorder Psychol Sci 11 1 6 PubMed CrossRef Gehring, WJ, Coles, MGH, Meyer, DE, Donchin, E 1990 The error-related negativity: an event-related brain potential accompanying errors Psychophysiology 27 34 CrossRef Goodman, WK, Price, LH, Rasmussen, SA, Mazure, C, Fleischmann, RL, Hill, CL, Heninger, GR, Charney, DS 1989 The Yale-Brown obsessive compulsive scale. I. Development, use, and reliability Arch Gen Psychiatry 46 1006 1011 PubMed Gratton, G, Coles, MG, Donchin, E 1983 A new method for off-line removal of ocular artifact Electroen Clin Neuro 55 468 484 CrossRef Hamilton, M 1960 A rating scale for depression J Neurol Neurosurg Psychiatry 23 56 62 PubMed Hamilton, M 1976 HAMA. The Hamilton anxiety scale Guy, W eds. ECDEU assessment manual for psychopharmacologyRevised edition Rockville Maryland Herrmann, MJ, Jacob, C, Unterecker, S, Fallgatter, AJ 2003 Reduced response-inhibition in obsessive-compulsive disorder measured with topographic evoked potential mapping Psychiatry Res 120 265 271 PubMed CrossRef Holroyd, CB 2004 A note on the Oddball N200 and the Feedback ERN Ullsperger, M Falkenstein, M eds. Errors, conflicts, and the brain Max Planck Institute for Human Cognitive and Brain Sciences Leipzig 211 218 Insel, TR 1992 Toward a neuroanatomy of obsessive-compulsive disorder Arch Gen Psychiatry 49 739 744 PubMed Johannes, S, Wieringa, BM, Nager, W, Rada, D, Dengler, R, Emrich, HM, Munte, TF, Dietrich, DE 2001 Discrepant target detection and action monitoring in obsessive-compulsive disorder Psychiatr Res 108 101 110 CrossRef Kaiser, S, Unger, J, Kiefer, M, Markela, J, Mundt, C, Weisbrod, M 2003 Executive control deficit in depression: event-related potentials in a Go/Nogo task Psychiatr Res 122 169 184 CrossRef Kiefer, M, Marzinzik, F, Weisbrod, M, Scherg, M, Spitzer, M 1998 The time course of brain activations during response inhibition: evidence from event-related potentials in a go/no go task Neuroreport 9 765 770 PubMed CrossRef Kim, MS, Kim, YY, Yoo, SY, Kwon, JS 2007 Electrophysiological correlates of behavioral response inhibition in patients with obsessive-compulsive disorder Depress Anxiety 24 22 31 PubMed CrossRef Kopp, B, Mattler, U, Goertz, R, Rist, F 1996 N2, P3 and the lateralized readiness potential in a nogo task involving selective response priming Electroencephalogr Clin Neurophysiol 99 19 27 PubMed Malloy, P, Rasmussen, S, Braden, W, Haier, RJ 1989 Topographic evoked potential mapping in obsessive-compulsive disorder: evidence of frontal lobe dysfunction Psychiatr Res 28 63 71 CrossRef McGuire, PK, Bench, CJ, Frith, CD, Marks, IM, Frackowiak, RS, Dolan, RJ 1994 Functional anatomy of obsessive-compulsive phenomena Br J Psychiatry 164 459 468 PubMed Morault, PM, Bourgeois, M, Laville, J, Bensch, C, Paty, J 1997 Psychophysiological and clinical value of event-related potentials in obsessive-compulsive disorder Biol Psychiatry 42 46 56 PubMed CrossRef Morault, PM, Guillem, F, Bourgeois, M, Paty, J 1998 Improvement predictors in obsessive-compulsive disorder. An event-related potential study Psychiatr Res 81 87 96 CrossRef Nieuwenhuis, S, Yeung, N, van den Wildenberg, W, Ridderinkhof, KR 2003 Electrophysiological correlates of anterior cingulate function in a go/no-go task: effects of response conflict and trial type frequency Cogn Affect Behav Neurosci 3 17 26 PubMed Oldfield, RC 1971 The assessment and analysis of handedness: the Edinburgh inventory Neuropsychologia 9 97 113 PubMed CrossRef Overall, JE, Gorham, DR 1962 The brief psychiatric rating scale Psychol Rep 10 799 812 CrossRef Pailing, PE, Segalowitz, SJ, Dywan, J, Davies, PL 2002 Error negativity and response control Psychophysiology 39 198 206 PubMed CrossRef Peers, PV, Ludwig, CJ, Rordan, C, Cusack, R, Bonfiglioli, C, Bundesen, C, Driver, J, Antoun, N, Duncan, J 2005 Attentional functions of parietal and frontal cortex Cereb Cortex 15 1469 1484 PubMed CrossRef Perani, D, Colombo, C, Bressi, S, Bonfanti, A, Grassi, F, Scarone, S, Bellodi, L, Smeraldi, E, Fazio, F 1995 [18F]FDG PET study in obsessive-compulsive disorder. A clinical/metabolic correlation study after treatment Br J Psychiatry 166 244 250 PubMed CrossRef Pfefferbaum, A, Ford, JM, Weller, BJ, Kopell, BS 1985 ERPs to response production and inhibition Electroencephalogr Clin Neurophysiol 60 423 434 PubMed CrossRef Rauch, SL, Jenike, MA, Alpert, NM, Baer, L, Breiter, HC, Savage, CR, Fischman, AJ 1994 Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography Arch Gen Psychiatry 51 62 70 PubMed Rosenberg, DR, Dick, EL, O’Hearn, KM, Sweeney, JA 1997 Response-inhibition deficits in obsessive-compulsive disorder: an indicator of dysfunction in frontostriatal circuits J Psychiatry Neurosci 22 29 38 PubMed Ruchsow, M, Gron, G, Reuter, K, Spitzer, M, Hermle, L, Kiefer, M 2005 Error-related brain activity in patients with obsessive-compulsive disorder and in healthy controls J Psychophysiol 19 298 304 CrossRef Salisbury, DF, Griggs, CB, Shenton, ME, McCarley, RW 2004 The NoGo P300 ‘anteriorization’ effect and response inhibition Clin Neurophysiol 115 1550 1558 PubMed CrossRef Scheffers, MK, Coles, MGH, Bernstein, P, Gehring, WJ, Donchin, E 1996 Event-related brain potentials and error-related processing: an analysis of incorrect responses to go and no-go stimuli Psychophysiology 33 42 53 PubMed CrossRef Strik, WK, Fallgatter, AJ, Brandeis, D, Pascual-Marqui, RD 1998 Three-dimensional tomography of event-related potentials during response inhibition: evidence for phasic frontal lobe activation Electroencephalogr Clin Neurophysiol 108 406 413 PubMed CrossRef Stuss, DT, Benson, DF 1983 Frontal lobe lesions and behavior Kertesz, A eds. Localization in neuropsychology Academic Press New York 429 449 Swedo, SE, Schapiro, MB, Grady, CL, Cheslow, DL, Leonard, HL, Kumar, A, Friedland, R, Rapoport, SI, Rapoport, JL 1989 Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder Arch Gen Psychiatry 46 518 523 PubMed Towey, J, Bruder, G, Hollander, E, Friedman, D, Erhan, H, Liebowitz, M, Sutton, S 1990 Endogenous event-related potentials in obsessive-compulsive disorder Biol Psychiatry 28 92 98 PubMed CrossRef Towey, J, Bruder, G, Tenke, C, Leite, P, DeCaria, C, Friedman, D, Hollander, E 1993 Event-related potential and clinical correlates of neurodysfunction in obsessive-compulsive disorder Psychiatr Res 49 167 181 CrossRef Wiedemann, G, Mühlberger, M 2002 Psychophysiology of anxiety disorders D’Haenen, H den Boer, JA Willner, P eds. Biological psychiatry Wiley Chichester 959 974 CrossRef Yeung, N, Cohen, JD, Botvinick, MM 2004 The neural basis of error detection: conflict monitoring and the error-related negativity Psychol Rev 111 931 959 PubMed CrossRef