, Volume 114, Issue 8, pp 1027-1031
Date: 16 Apr 2007

Continuous delivery of rotigotine decreases extracellular dopamine suggesting continuous receptor stimulation

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Rotigotine, a non-ergolinic dopamine receptor agonist for treatment of Parkinson’s disease was continuously administered over 48 h (0.5 mg/kg s.c., slow release formulation) to conscious rats striatally implanted with a microdialysis probe. Subsequently, the levels of rotigotine increased to a maximum of 3.42 + 2.1 nmol/l and remained at a level of 2.81 ± 0.82 nmol/l for 48 h. Concomitantly, the dopamine levels consistently decreased to 20% of the control level. This suggests that the sustained administration of rotigotine provides stable extracellular drug levels in the striatum resulting in continuous stimulation of dopamine receptors.