Journal of Neural Transmission

, Volume 114, Issue 8, pp 1065–1068

Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression

  • S. Anttila
  • K. Huuhka
  • M. Huuhka
  • R. Rontu
  • M. Hurme
  • E. Leinonen
  • T. Lehtimäki
Article

DOI: 10.1007/s00702-007-0705-9

Cite this article as:
Anttila, S., Huuhka, K., Huuhka, M. et al. J Neural Transm (2007) 114: 1065. doi:10.1007/s00702-007-0705-9

Summary

Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants. We attempt to show that the interaction between 5-HT1A and BDNF polymorphism predicts the risk of treatment-resistant depression. The sample consists of 119 patients with treatment-resistant MDD and 392 controls. 5-HT1A C1019G and BDNF G196A (Val66Met) polymorphisms were studied. The combination of 5-HT1A GG and BDNF GA + AA genotypes is associated with an increased risk of depression.

Keywords: 5-HT1A, BDNF, polymorphism, major depression, treatment-resistant, electroconvulsive therapy 

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • S. Anttila
    • 1
    • 2
  • K. Huuhka
    • 1
    • 3
  • M. Huuhka
    • 1
    • 3
  • R. Rontu
    • 1
    • 2
  • M. Hurme
    • 4
    • 5
  • E. Leinonen
    • 1
    • 3
  • T. Lehtimäki
    • 1
    • 2
  1. 1.Medical School, University of TampereTampereFinland
  2. 2.Laboratory of Atherosclerosis Genetics, Centre for Laboratory Medicine, Department of Clinical ChemistryTampere University HospitalTampereFinland
  3. 3.Department of PsychiatryTampere University HospitalPitkäniemiFinland
  4. 4.Department of Microbiology and ImmunologyMedical School, University of TampereTampereFinland
  5. 5.The Laboratory CentreTampere University HospitalTampereFinland

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