Journal of Neural Transmission

, 114:1081

Dopamine and N-methyl-D-aspartate receptor expression in peripheral blood of patients undergoing alcohol withdrawal

Authors

  • T. Biermann
    • Department of Psychiatry and PsychotherapyFriedrich-Alexander-University
  • D. Bönsch
    • Department of Psychiatry and PsychotherapyFriedrich-Alexander-University
  • U. Reulbach
    • Department of Psychiatry and PsychotherapyFriedrich-Alexander-University
  • J. Kornhuber
    • Department of Psychiatry and PsychotherapyFriedrich-Alexander-University
  • S. Bleich
    • Department of Psychiatry and PsychotherapyFriedrich-Alexander-University
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DOI: 10.1007/s00702-007-0661-4

Cite this article as:
Biermann, T., Bönsch, D., Reulbach, U. et al. J Neural Transm (2007) 114: 1081. doi:10.1007/s00702-007-0661-4
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Summary

The aim of the present pilot study was to explore whether a change in cerebral receptors can be demonstrated in human peripheral blood lymphocytes during alcohol withdrawal. Dopamine (D1 and D2) and NMDA (1 and 2B) receptor expressions of 14 male patients suffering from alcohol-dependency were assessed through quantitative RT-PCR. A significant difference in D1 receptor expression (T = 2.361; p = 0.035) in terms of up-regulation could be shown, though there were no significant changes concerning D2, NMDA1 or NMDA2B receptor expression.

Keywords: Dopamine receptor, NMDA receptor, mRNA, alcohol withdrawal
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© Springer-Verlag 2007