Journal of Neural Transmission

, Volume 114, Issue 4, pp 445–450

Homocysteine levels in aqueous humor and plasma of patients with primary open-angle glaucoma

  • J. B. Roedl
  • S. Bleich
  • U. Reulbach
  • N. von Ahsen
  • U. Schlötzer-Schrehardt
  • R. Rejdak
  • G. O. H. Naumann
  • F. E. Kruse
  • J. Kornhuber
  • A. G. M. Jünemann
Article

DOI: 10.1007/s00702-006-0556-9

Cite this article as:
Roedl, J., Bleich, S., Reulbach, U. et al. J Neural Transm (2007) 114: 445. doi:10.1007/s00702-006-0556-9

Summary

We determined homocysteine (Hcy) levels in aqueous humor (AH) and plasma and their association with B-vitamin levels in patients with primary open-angle glaucoma (POAG) and controls. Both AH Hcy and plasma Hcy levels were significantly increased in POAG, and elevation of AH Hcy and plasma Hcy was a significant risk factor for POAG. In contrast to controls, neither plasma nor AH Hcy of POAG patients demonstrated a significant association with important non-genetic determinants of elevated Hcy such as low B-vitamin levels, increasing age and caffeine consumption. Considering that Hcy is a neurotoxin that induces apoptotic retinal ganglion cell death via stimulation of the N-methyl-D-asparate (NMDA) receptor, increased Hcy concentrations in AH and plasma might contribute to the optic nerve damage in POAG.

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • J. B. Roedl
    • 1
  • S. Bleich
    • 2
  • U. Reulbach
    • 2
    • 3
  • N. von Ahsen
    • 4
  • U. Schlötzer-Schrehardt
    • 1
  • R. Rejdak
    • 1
    • 5
    • 6
  • G. O. H. Naumann
    • 1
  • F. E. Kruse
    • 1
  • J. Kornhuber
    • 2
  • A. G. M. Jünemann
    • 1
  1. 1.Department of Ophthalmology and University Eye HospitalFriedrich-Alexander-UniversityErlangen-NurembergGermany
  2. 2.Department of Psychiatry and PsychotherapyFriedrich-Alexander-UniversityErlangen-NurembergGermany
  3. 3.Department of Medical Informatics, Biometry and EpidemiologyFriedrich-Alexander-UniversityErlangen-NurembergGermany
  4. 4.Department of Clinical ChemistryGeorg-August-UniversityGoettingenGermany
  5. 5.1st Department of OphthalmologyUniversity Eye HospitalLublinPoland
  6. 6.Medical Research CentrePolish Academy of SciencesWarsawPoland