Journal of Neural Transmission

, Volume 114, Issue 3, pp 331–335

Striatal FP-CIT uptake differs in the subtypes of early Parkinson’s disease

Authors

  • J. Spiegel
    • Department of NeurologySaarland University
  • D. Hellwig
    • Department of Nuclear MedicineSaarland University
  • S. Samnick
    • Department of Nuclear MedicineSaarland University
  • W. Jost
    • Department of NeurologyDeutsche Klinik fur Diagnostik
  • M.-O. Möllers
    • Department of Nuclear MedicineSaarland University
  • K. Fassbender
    • Department of NeurologySaarland University
  • C.-M. Kirsch
    • Department of Nuclear MedicineSaarland University
  • U. Dillmann
    • Department of NeurologySaarland University
Article

DOI: 10.1007/s00702-006-0518-2

Cite this article as:
Spiegel, J., Hellwig, D., Samnick, S. et al. J Neural Transm (2007) 114: 331. doi:10.1007/s00702-006-0518-2

Summary.

In idiopathic Parkinson’s disease (PD), a tremor-dominant type (TDT), an akinetic-rigid type (ART), and a mixed type (MT) are distinguished. We compared cerebral [I-123]FP-CIT SPECT in the PD subtypes (67 patients Hoehn and Yahr stage 1:26 with ART, 19 with MT, 22 with TDT). We measured the ratios putamen/occipital lobe binding and caudate nucleus/occipital lobe binding. Parkinsonian motor symptoms were quantified by UPDRS motor scale. In both putamen and caudate nucleus contralateral to the clinically affected body side TDT patients showed a significantly higher FP-CIT uptake than ART or MT patients (ANOVA; p<0.01). Contralateral putamen and caudate nucleus FP-CIT uptake correlated significantly with severity of rigidity (p<0.01) and hypokinesia (p<0.01) but not with severity of resting or postural tremor (p>0.05). The missing correlation between striatal FP-CIT uptake and tremor suggests, that further systems besides the nigrostriatal dopaminergic system may contribute to generation of parkinsonian tremor.

Keywords: Parkinson’s disease, FP-CIT SPECT

Copyright information

© Springer-Verlag 2006