Journal of Neural Transmission

, 113:1909

Effect of cabergoline added to levodopa treatment on sleep-wake cycle in idiopathic Parkinson’s disease: an open label 24-hour polysomnographic study

Authors

  • A. Romigi
    • University of Rome “Tor Vergata” Policlinico Tor Vergata Servizio di Neurofisiopatologia Centro di Medicina del Sonno
    • IRCCS Fondazione Santa Lucia
  • P. Stanzione
    • University of Rome “Tor Vergata” Dipartimento di Neuroscienze Clinica Neurologica
    • IRCCS Fondazione Santa Lucia
  • M. G. Marciani
    • University of Rome “Tor Vergata” Policlinico Tor Vergata Servizio di Neurofisiopatologia Centro di Medicina del Sonno
    • IRCCS Fondazione Santa Lucia
  • F. Izzi
    • University of Rome “Tor Vergata” Dipartimento di Neuroscienze Clinica Neurologica
  • F. Placidi
    • University of Rome “Tor Vergata” Policlinico Tor Vergata Servizio di Neurofisiopatologia Centro di Medicina del Sonno
    • IRCCS Fondazione Santa Lucia
  • A. Cervellino
    • University of Rome “Tor Vergata” Policlinico Tor Vergata Servizio di Neurofisiopatologia Centro di Medicina del Sonno
  • P. Giacomini
    • Università di Roma La Sapienza, Clinica Neurologica
  • L. Brusa
    • University of Rome “Tor Vergata” Dipartimento di Neuroscienze Clinica Neurologica
  • K. Grossi
    • University of Rome “Tor Vergata” Policlinico Tor Vergata Servizio di Neurofisiopatologia Centro di Medicina del Sonno
  • M. Pierantozzi
    • University of Rome “Tor Vergata” Policlinico Tor Vergata Servizio di Neurofisiopatologia Centro di Medicina del Sonno
    • IRCCS Fondazione Santa Lucia
Article

DOI: 10.1007/s00702-006-0490-x

Cite this article as:
Romigi, A., Stanzione, P., Marciani, M. et al. J Neural Transm (2006) 113: 1909. doi:10.1007/s00702-006-0490-x

Summary.

Few studies focused on the effects of cabergoline on sleep-wake cycle in PD. Twelve patients affected by PD treated with levodopa as monotherapy underwent two 24-hour ambulatory polysomnographic (A-PSG) sessions twice: in baseline condition (levodopa as monotherapy) and after addition of cabergoline. In each condition, a subjective evaluation of sleep quality and daytime sleepiness was obtained by means of Parkinson’s disease Sleep Scale (PDSS) and the Epworth Sleepiness Scale. The statistical analysis of sleep parameters revealed a significant increase of sleep efficiency and slow wave sleep under cabergoline. The PDSS total score showed a significant improvement of overall sleep quality after cabergoline. No significant changes in daytime sleepiness were observed. No patient referred and/or showed sleep attacks before and after addition of cabergoline. We hypothesize that the long-lasting effect of cabergoline may improve the objective quality of nocturnal sleep in PD patients complaining nocturnal motor disability without inducing daytime sleepiness.

Keywords: Parkinson’s disease, sleep, excessive daytime somnolence, cabergoline, polysomnography, Parkinson’s disease Sleep Scale, Epworth Sleepiness Scale

Copyright information

© Springer-Verlag 2006