Effects of stimulus-response compatibility in Parkinson’s disease: a psychophysiological analysis
First Online: 09 February 2006 Received: 28 April 2005 Accepted: 26 November 2005 DOI:
10.1007/s00702-005-0430-1 Cite this article as: Falkenstein, M., Willemssen, R., Hohnsbein, J. et al. J Neural Transm (2006) 113: 1449. doi:10.1007/s00702-005-0430-1 Summary.
The present study investigated the mechanisms underlying stimulus-response compatibility effects in Parkinson’s disease patients and matched controls. Since basal ganglia are involved in the selection and inhibition of competing responses we examined whether basal ganglia dysfunction in Parkinson’s disease leads to greater interference effects compared to the control subjects. Reaction times and lateralized movement-related cortical potentials (lateralized readiness potential: LRP) were recorded in two modified Eriksen flanker tasks.
Both groups were influenced by compatibility conditions; interference was seen as enhanced reaction time and error rate, as well as incorrect early LRP and delayed late LRP in incongruent trials. Altogether, behavioral and electrophysiological measures showed the interference to be rather smaller for the patients than for the controls. In contrast, facilitation did not differ among groups. Hence the claim that Parkinson’s disease patients are more influenced than controls by interfering directional stimuli appears not always valid.
Keywords: Basal ganglia, Parkinson’s disease, stimulus-response compatibility, flanker task, lateralized readiness potential. References Alexander, GE, Crutcher, MD 1990 Functional architecture of basal ganglia circuits: neural substrates of parallel processing Trends Neurosci 109 266 271 CrossRef Alexander, GE, DeLong, MR, Strick, PL 1986 Parallel organization of functionally segregated circuits linking basal ganglia and cortex Annu Rev Neurosci 9 357 381 PubMed CrossRef Benton, AL 1968 Differential behavioral effects in frontal lobe disease Neuropsychologia 6 53 60 CrossRef Brown, RG, Jahanshahi, M, Marsden, CD 1993 Response choice in Parkinson’s disease. The effects of uncertainty and stimulus-response compatibility Brain 116 869 885 PubMed Brown, RG, Marsden, C 1988 Internal versus external cues and the control of attention in Parkinson’s disease Brain 111 323 345 PubMed Brown, P, Marsden, CD 1998 What do the basal ganglia do? Lancet 351 1801 1804 PubMed CrossRef Chevalier, G, Deniau, JM 1990 Disinhibition as a basic process in the expression of striatal functions Trends Neurosci 13 277 280 PubMed CrossRef Coles, MGH 1989 Modern mind-brain reading: psychophysiology, physiology, and cognition Psychophysiology 26 251 269 PubMed Eriksen, BA, Eriksen, CW 1974 Effects of noise letters upon the identification of a nonsearch task Percept Psychophys 16 143 149 Eriksen, CW, Schultz, DW 1979 Information processing in visual search: a continuous flow conception and experimental results Percept Psychophys 25 249 263 PubMed Fahn, S Elton, RL Members of the UPDRS Development Committee 1987 Unified Parkinson’s Disease Rating Scale Fahn, S Marsden, CD Calne, DB Goldstein, M eds. Recent developments in Parkinson’s disease Macmillan Healthcare Information Florham Park, NJ 153 163 Flowers, JH 1990 Priming effects in perceptual classification Percept Psychophys 47 135 148 PubMed Gratton, G, Coles, MGH, Donchin, E 1983 A new method for off-line removal of ocular artifact Electroencephalogr Clin Neurophysiol 55 468 484 PubMed CrossRef Henik, A, Singh, J, Beckley, DJ, Rafal, RD 1993 Disinhibition of automatic word reading in Parkinson’s disease Cortex 29 589 599 PubMed Jackson, S, Houghton, G 1995 Sensorimotorselection and the basal ganglia: a neural network model Houk, JG Davis, JL Beiser, DG eds. Models of information processing in the basal ganglia IVIT Press Cambridge 337 374 Jones, DL, Bradshaw, JL, Phillips, JG, Iansek, R, Mattingley, JB, Bradshaw, JA 1994 Allocation of attention to programming of movement sequences in Parkinson’s disease J Clin Exp Neuropsychol 16 117 128 PubMed Jurkowski, AJ, Hackley, SA, Gratton, G 2002 Dissociation of age and Parkinson’s disease effects in a response conflict. Society for Psychophysiological Research. Abstracts, Forty-Second Annual Meeting, Washington, DC Psychophysiology 39 8 Karayanidis, F 1989 Parkinson’s disease: a conceptualization of neuropsychological deficits within an information-processing framework Biol Psychol 29 149 179 PubMed CrossRef Kopp, B, Rist, F, Mattler, U 1996 N200 in the flanker task as a neurobehavioral tool for investigating executive control Psychophysiology 33 282 294 PubMed Kornblum, S, Hasbroucq, T, Osman, A 1990 Dimensional overlap: cognitive basis for stimulus-response compatibility – a model and taxonomy Psychol Rev 97 253 270 PubMed CrossRef Lee, SS, Wild, K, Hollnagel, C, Grafman, J 1999 Selective visual attention in patients with frontal lobe lesions or Parkinson’s disease Neuropsychologia 37 595 604 PubMed CrossRef Low, KA, Miller, J, Vierck, E 2002 Response slowing in Parkinson’s disease. A psychophysiological analysis of premotor and motor processes Brain 125 1980 1994 PubMed CrossRef Maddox, WT, Filoteo, JV, Delis, DC, Salmon, DP 1996 Visual selective attention deficits in Patients with Parkinson’s disease: a quantitative model-based approach Neuropsychology 10 197 218 CrossRef Mattler, U 2003 Delayed flanker effects in lateralized readiness potentials Exp Brain Res 151 272 288 PubMed CrossRef Miller, J, Patterson, T, Ulrich, R 1998 Jackknife-based method for measuring LRP onset latency differences Psychophysiology 35 99 115 PubMed CrossRef Mink, JW 1996 The basal ganglia: focused selection and inhibition of competing motor programs Prog Neurobiol 50 381 425 PubMed CrossRef Nelson, HE 1976 A modified card sorting test sensitive to frontal lobe defect Cortex 12 313 324 PubMed Praamstra, P, Plat, EM, Meyer, AS, Horstink, MWIM 1999 Motor cortex activation in Parkinson’s disease: dissociation of electrocortical and peripheral measures of response generation Mov Disord 14 790 799 PubMed CrossRef Praamstra, P, Stegeman, DF, Cools, AR, Horstink, MWIM 1998 Reliance on external cues for movement initiation in Parkinson’s disease. Evidence from movement-related potentials Brain 121 167 177 PubMed CrossRef Sharpe, MH 1990 Distractibility in early Parkinson’s disease Cortex 26 239 246 PubMed Sharpe, MH 1992 Auditory attention in early Parkinson’s disease: an impairment in focused attention Neuropsychologia 30 101 106 PubMed CrossRef Sommer, W, Ulrich, R, Leuthold, H 1996 Das Lateralisierte Bereitschaftspotential als psychophysiologischer Zugang bei der Untersuchung kognitiver Prozesse Psychol Rundschau 47 1 14 Wascher, E, Reinhard, M, Wauschkuhn, B, Verleger, R 1999 Spatial S-R compatibility with centrally presented stimuli: an event-related asymmetry study on dimensional overlap J Cogn Neurosci 11 214 229 PubMed CrossRef Wascher, E, Verleger, R, Vieregge, P, Jaskowski, P, Koch, S, Kömpf, D 1997 Responses to cued signals in Parkinson’s disease. Distinguishing between disorders of cognition and of activation Brain 120 1355 1375 PubMed CrossRef Willemssen, R, Hoormann, J, Hohnsbein, J, Falkenstein, M 2004 Central and parietal event-related lateralizations in a flanker task Psychophysiology 41 762 771 PubMed CrossRef Wylie, SA, Stout, JC, Bashore, TR 2005 Activation of conflicting responses in Parkinson’s disease: evidence for degrading and facilitating effects on response time Neuropsychologia 43 1033 1043 PubMed CrossRef Zeef, EJ, Kok, A 1993 Age-related differences in the timing of stimulus and response processes during visual selective attention: performance and psychophysiological analyses Psychophysiology 30 138 151 PubMed