Journal of Neural Transmission

, Volume 113, Issue 5, pp 659–670

Imaging of serotonin transporters and its blockade by citalopram in patients with major depression using a novel SPECT ligand [123I]-ADAM

  • N. Herold
  • K. Uebelhack
  • L. Franke
  • H. Amthauer
  • L. Luedemann
  • H. Bruhn
  • R. Felix
  • R. Uebelhack
  • M. Plotkin
Article

DOI: 10.1007/s00702-005-0429-7

Cite this article as:
Herold, N., Uebelhack, K., Franke, L. et al. J Neural Transm (2006) 113: 659. doi:10.1007/s00702-005-0429-7

Summary.

We studied the midbrain SERT availability in patients with major depression and assessed the relation of SERT occupancy by citalopram to the treatment response. 21 non-medicated patients with major depression and 13 healthy controls were examined by [123I]-ADAM SPECT. The midbrain SERT availability (SERT V3″) was calculated using individual MRI scans. In 13/21 patients SPECT was repeated 7 days after oral medication with citalopram (10 mg/day). We found no significant difference in the mean midbrain SERT availability between the studied patients with major depression and healthy controls (0.86 ± 0.27 vs. 0.71 ± 0.44, p = 0.069). The mean SERT occupancy accounted to 61%. The degree of SERT blockade by citalopram did not correlate with the reduction in HAMD total score. Treatment with low-dosed citalopram caused individually variable occupancy of the midbrain-SERT and a rapid clinical improvement in 54% of the investigated patients.

Keywords: Serotonin transporters, major depression, [123I]ADAM, single photon emission tomography (SPECT), citalopram, midbrain. 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • N. Herold
    • 1
  • K. Uebelhack
    • 2
  • L. Franke
    • 2
  • H. Amthauer
    • 1
  • L. Luedemann
    • 1
  • H. Bruhn
    • 1
  • R. Felix
    • 1
  • R. Uebelhack
    • 2
  • M. Plotkin
    • 1
  1. 1.Department of RadiologyNuclear Medicine and Radiooncology, Campus VirchowBerlinGermany
  2. 2.Department of PsychiatryCampus Mitte, Charité UniversitätsmedizinBerlinGermany

Personalised recommendations