Journal of Neural Transmission

, Volume 113, Issue 10, pp 1435–1439

The plasma alpha-synuclein levels in patients with Parkinson’s disease and multiple system atrophy

  • P. H. Lee
  • G. Lee
  • H. J. Park
  • O. Y. Bang
  • I. S. Joo
  • K. Huh
Article

DOI: 10.1007/s00702-005-0427-9

Cite this article as:
Lee, P., Lee, G., Park, H. et al. J Neural Transm (2006) 113: 1435. doi:10.1007/s00702-005-0427-9

Summary.

α-Synuclein, a synaptic protein of unknown function, is a major component of Lewy bodies and may play a role in the pathophysiological process of Parkinson’s disease (PD). In this study, we measured the plasma α-synuclein levels in 105 patients with PD, 38 patients with multiple system atrophy (MSA), and 51 age-matched controls. The α-synuclein level was significantly elevated in patients with PD (79.9 ± 4.0 pg/ml, p < 0.001) and in those with MSA (78.1 ± 3.5 pg/ml, p = 0.019) compared with the level in controls (76.1 ± 3.9 pg/ml). The α-synuclein level was higher in patients with PD than in those with MSA (79.9 ± 4.0 vs 78.1 ± 3.5, p = 0.016). Our study demonstrated that the α-synuclein level in plasma is elevated in patients with PD and MSA.

Keywords: α-Synuclein, Parkinson’s disease, multiple system atrophy.

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • P. H. Lee
    • 1
  • G. Lee
    • 2
  • H. J. Park
    • 1
  • O. Y. Bang
    • 1
  • I. S. Joo
    • 1
  • K. Huh
    • 1
  1. 1.Department of NeurologyAjou University School of MedicineSuwonSouth Korea
  2. 2.Brain Disease Research CenterAjou University School of MedicineSuwonSouth Korea