Article

Journal of Neural Transmission

, Volume 113, Issue 10, pp 1435-1439

First online:

The plasma alpha-synuclein levels in patients with Parkinson’s disease and multiple system atrophy

  • P. H. LeeAffiliated withDepartment of Neurology, Ajou University School of Medicine
  • , G. LeeAffiliated withBrain Disease Research Center, Ajou University School of Medicine
  • , H. J. ParkAffiliated withDepartment of Neurology, Ajou University School of Medicine
  • , O. Y. BangAffiliated withDepartment of Neurology, Ajou University School of Medicine
  • , I. S. JooAffiliated withDepartment of Neurology, Ajou University School of Medicine
  • , K. HuhAffiliated withDepartment of Neurology, Ajou University School of Medicine

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Summary.

α-Synuclein, a synaptic protein of unknown function, is a major component of Lewy bodies and may play a role in the pathophysiological process of Parkinson’s disease (PD). In this study, we measured the plasma α-synuclein levels in 105 patients with PD, 38 patients with multiple system atrophy (MSA), and 51 age-matched controls. The α-synuclein level was significantly elevated in patients with PD (79.9 ± 4.0 pg/ml, p < 0.001) and in those with MSA (78.1 ± 3.5 pg/ml, p = 0.019) compared with the level in controls (76.1 ± 3.9 pg/ml). The α-synuclein level was higher in patients with PD than in those with MSA (79.9 ± 4.0 vs 78.1 ± 3.5, p = 0.016). Our study demonstrated that the α-synuclein level in plasma is elevated in patients with PD and MSA.

Keywords: α-Synuclein, Parkinson’s disease, multiple system atrophy.