Journal of Neural Transmission

, Volume 112, Issue 11, pp 1475–1478

Effects of nicotine on neurogenesis and plasticity of hippocampal neurons


  • A. S. Shingo
    • Hyogo University School of Health Sciences
  • S. Kito
    • Hyogo University School of Health Sciences
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DOI: 10.1007/s00702-005-0370-2

Cite this article as:
Shingo, A. & Kito, S. J Neural Transm (2005) 112: 1475. doi:10.1007/s00702-005-0370-2


To study nicotine’s effects on neurogenesis in the dentate gyrus of the hippocampus, nicotine was injected intraperitoneally into adult rats. After sacrificing, the hippocampal formation was processed for immunohistochemical staining of PSA-NCAM, NeuN and GFAP. Nicotine decreased numbers of PSA-NCAM(+) and NeuN(+) cells dose-dependently.

Keywords: Nicotine, neurogenesis, plasticity, hippocampus, PSA-NCAM.

Copyright information

© Springer-Verlag/Wien 2005