Effects of nicotine on neurogenesis and plasticity of hippocampal neurons Authors
Received: 10 May 2005 Accepted: 15 July 2005 DOI:
Cite this article as: Shingo, A. & Kito, S. J Neural Transm (2005) 112: 1475. doi:10.1007/s00702-005-0370-2 Summary.
To study nicotine’s effects on neurogenesis in the dentate gyrus of the hippocampus, nicotine was injected intraperitoneally into adult rats. After sacrificing, the hippocampal formation was processed for immunohistochemical staining of PSA-NCAM, NeuN and GFAP. Nicotine decreased numbers of PSA-NCAM(+) and NeuN(+) cells dose-dependently.
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