Journal of Neural Transmission

, Volume 112, Issue 12, pp 1669–1675

Sleep disorders in multiple system atrophy

  • I. Ghorayeb
  • B. Bioulac
  • F. Tison
Article

DOI: 10.1007/s00702-005-0348-7

Cite this article as:
Ghorayeb, I., Bioulac, B. & Tison, F. J Neural Transm (2005) 112: 1669. doi:10.1007/s00702-005-0348-7

Summary.

Complaints about sleep disorders and excessive daytime sleepiness are common among patients with multiple system atrophy. The diffuse neurodegenerative process that encompasses the key structures involved in the regulation of the sleep/wake transition and respiratory function may account for these complaints and for the most frequent polysomnographic findings in MSA, i.e., sleep-related breathing disturbances and REM sleep behaviour disorder, which are both treatable conditions. Nocturnal stridor is an inspiratory sound produced by complex vocal cord muscle dysfunction. Often occurring with sleep apnoea, stridor is associated with decreased survival. REM sleep behaviour disorder, a parasomnia characterized by loss of normal skeletal muscle atonia during REM sleep with prominent motor activity, is detected in almost all patients. The pathophysiology of both disorders is partially elucidated but increasing evidence points to the role of basal ganglia dysfunction.

Keywords: Multiple system atrophy, sleep disorders, excessive daytime sleepiness, stridor, sleep apnoea, REM sleep behaviour disorder.

Copyright information

© Springer-Verlag/Wien 2005

Authors and Affiliations

  • I. Ghorayeb
    • 1
  • B. Bioulac
    • 1
  • F. Tison
    • 2
  1. 1.Service d’Explorations Fonctionnelles du Système NerveuxBordeauxFrance
  2. 2.Service de Neurologie, CHU de BordeauxBordeauxFrance