Journal of Neural Transmission

, Volume 112, Issue 8, pp 1107–1113

Negative association between Catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and persistent tardive dyskinesia in schizophrenia

  • I.-C. Lai
  • Y.-C. Wang
  • C.-C. Lin
  • Y.-M. Bai
  • D.-L. Liao
  • S.-C. Yu
  • C.-Y. Lin
  • J.-Y. Chen
  • Y.-J. Liou
Article

DOI: 10.1007/s00702-004-0252-6

Cite this article as:
Lai, IC., Wang, YC., Lin, CC. et al. J Neural Transm (2005) 112: 1107. doi:10.1007/s00702-004-0252-6

Summary.

Chronic administration of typical antipsychotic agents, which mainly act on the dopamine receptors, implicates a role of dopamine system on the susceptibility of tardive dyskinesia (TD). In the present study, the association between a functional Val158Met polymorphism of Catechol-O-methyltransferase (COMT) gene and TD occurrence and TD severity was investigated in 299 Chinese schizophrenic patients with long-term antipsychotic treatment (TD: 166, non-TD: 133). After adjusting the effects of confounding factors, there was no significant association between COMT genotype and TD occurrence (p=0.367). Among TD patients, we found no significant correlation between COMT genotypes and the total scores of abnormal involuntary movement scale (AIMS) (p=0.629). We concluded that this COMT polymorphism might not play a major role in the susceptibility of TD nor on the severity of TD.

Keywords: Catechol-O-methyltransferase, COMT, tardive dyskinesia, polymorphism, association study, antipsychotics. 

Copyright information

© Springer-Verlag/Wien 2004

Authors and Affiliations

  • I.-C. Lai
    • 1
  • Y.-C. Wang
    • 1
    • 2
  • C.-C. Lin
    • 1
    • 3
  • Y.-M. Bai
    • 1
    • 4
  • D.-L. Liao
    • 5
  • S.-C. Yu
    • 6
  • C.-Y. Lin
    • 1
  • J.-Y. Chen
    • 1
  • Y.-J. Liou
    • 1
    • 7
  1. 1.Department of PsychiatryYuli Veterans Hospital, Tzu Chi UniversityHualienTaiwan
  2. 2.Institute of Medical Science, Tzu Chi UniversityHualienTaiwan
  3. 3.Institute of Clinical Medicine, Taipei Medical UniversityTaiwan
  4. 4.Institute of Public Health, National Yang-Ming UniversityTaipeiTaiwan
  5. 5.Pali Psychiatric Center HospitalTaipeiTaiwan
  6. 6.Department of Child PsychiatryYuli HospitalHualienTaiwan
  7. 7.Institute of Clinical Medicine, National Yang-Ming UniversityTaipeiTaiwan

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