Journal of Neural Transmission

, Volume 111, Issue 12, pp 1611–1616

Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism

Authors

  • D. Bönsch
    • Department of Psychiatry and PsychotherapyFriedrich-Alexander-University
  • B. Lenz
    • Department of Psychiatry and PsychotherapyFriedrich-Alexander-University
  • U. Reulbach
    • Department of Psychiatry and PsychotherapyFriedrich-Alexander-University
  • J. Kornhuber
    • Department of Psychiatry and PsychotherapyFriedrich-Alexander-University
  • S. Bleich
    • Department of Psychiatry and PsychotherapyFriedrich-Alexander-University
Rapid Communication

DOI: 10.1007/s00702-004-0232-x

Cite this article as:
Bönsch, D., Lenz, B., Reulbach, U. et al. J Neural Transm (2004) 111: 1611. doi:10.1007/s00702-004-0232-x

Summary.

Higher plasma homocysteine concentrations can influence genomic DNA methylation in peripheral blood cells. In the present controlled study we observed a significant increase (10%) of genomic DNA methylation in patients with alcoholism (t = −3.16, df = 158, p = 0.002) which was significantly associated with their elevated homocysteine levels (multiple linear regression, p < 0.001). Since methylation of DNA is an important epigenetic factor in regulation of gene expression these findings may have important implications for a possible subsequent derangement of epigenetic control these patients.

Keywords: Homocysteine, alcoholism, global DNA methylation, epigenetic control.
Download to read the full article text

Copyright information

© Springer-Verlag/Wien 2004