Journal of Neural Transmission

, Volume 112, Issue 5, pp 703–771

Brain-derived neurotrophic factor gene polymorphisms and Alzheimer’s disease

  • S. Matsushita
  • H. Arai
  • T. Matsui
  • T. Yuzuriha
  • K. Urakami
  • T. Masaki
  • S. Higuchi
Article

DOI: 10.1007/s00702-004-0210-3

Cite this article as:
Matsushita, S., Arai, H., Matsui, T. et al. J Neural Transm (2005) 112: 703. doi:10.1007/s00702-004-0210-3

Summary.

Several lines of evidence have made brain-derived neurotrophic factor (BDNF) an important candidate gene conferring risk for Alzheimer’s disease (AD). Recently, three studies reported an association between two single-nucleotide polymorphisms (SNP) – i.e., C270T and G196A – in the BDNF gene and AD. This attempt to confirm these associations in a larger AD sample included examination of the linkage disequilibrium of these two SNPs. Comparison of 487 Japanese AD subjects with 471 cognitively normal elderly controls showed higher frequencies of the G allele (60.5 vs. 55.5%, p = 0.028) and of both the GG and GA genotypes (85.8 vs. 79.8%, p = 0.025) of the G196A polymorphism in AD subjects than in controls and higher frequency of the T allele of the C270T polymorphism in AD subjects who were negative for apolipotrotein E4 (2.0 vs. 4.4%, p = 0.035) or positive for AD family history (2.8 vs. 7.1%, p = 0.046). These findings suggest that BDNF gene polymorphisms play some role in the development of AD.

Keywords: Alzheimer disease, apolipoprotein E (ApoE4), brain-derived neurotrophic factor, case-control study, genetic association, single nucleotide polymorphism (SNP). 

Copyright information

© Springer-Verlag/Wien 2004

Authors and Affiliations

  • S. Matsushita
    • 1
  • H. Arai
    • 2
  • T. Matsui
    • 2
  • T. Yuzuriha
    • 3
  • K. Urakami
    • 4
  • T. Masaki
    • 1
  • S. Higuchi
    • 1
  1. 1.Division of Clinical ResearchNational Hospital Organization, Kurihama Alcoholism CenterYokosukaJapan
  2. 2.Department of Geriatric and Complementary MedicineTohoku University Graduate School of MedicineSendaiJapan
  3. 3.Department of PsychiatryHizen National HospitalSefuriJapan
  4. 4.Department of Biological RegulationTottori University School of Life ScienceYonagoJapan

Personalised recommendations