Article

Journal of Neural Transmission

, Volume 112, Issue 1, pp 3-27

First online:

Neural plasticity: changes with age

  • M. Nieto-SampedroAffiliated withGrupo de Plasticidad Neural, Instituto Cajal de Neurobiología, CSIC, Madrid, and Unidad de Neurología Experimental, Hospital Nacional de Parapléjicos
  • , M. Nieto-DíazAffiliated withGrupo de Plasticidad Neural, Instituto Cajal de Neurobiología, CSIC, Madrid, and Unidad de Neurología Experimental, Hospital Nacional de Parapléjicos

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Summary.

Changes in the number, type and function of nervous system connections, in the morphology and function of glia and in neuron-glia interactions, are at the basis of vertebrate adjustment to changing environmental and physiological conditions. Collected under “neural plasticity”, these age-dependent changes underlie adaptations apparently as different as the physiological response to dehydration or learning, and its electrophysiological and morphological correlates.

Keywords: Learning, LTP, LTD, synapse renewal, axon sprouting, hebbosome, dendritic spines