Journal of Neural Transmission

, Volume 112, Issue 1, pp 3–27

Neural plasticity: changes with age

  • M. Nieto-Sampedro
  • M. Nieto-Díaz

DOI: 10.1007/s00702-004-0146-7

Cite this article as:
Nieto-Sampedro, M. & Nieto-Díaz, M. J Neural Transm (2005) 112: 3. doi:10.1007/s00702-004-0146-7


Changes in the number, type and function of nervous system connections, in the morphology and function of glia and in neuron-glia interactions, are at the basis of vertebrate adjustment to changing environmental and physiological conditions. Collected under “neural plasticity”, these age-dependent changes underlie adaptations apparently as different as the physiological response to dehydration or learning, and its electrophysiological and morphological correlates.

Keywords: Learning, LTP, LTD, synapse renewal, axon sprouting, hebbosome, dendritic spines 

Copyright information

© Springer-Verlag/Wien 2004

Authors and Affiliations

  • M. Nieto-Sampedro
    • 1
  • M. Nieto-Díaz
    • 1
  1. 1.Grupo de Plasticidad NeuralInstituto Cajal de Neurobiología, CSIC, Madrid, and Unidad de Neurología Experimental, Hospital Nacional de ParapléjicosToledoSpain

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