, Volume 112, Issue 1, pp 121-125
Date: 19 Mar 2004

Roles for gliotransmission in the nervous system

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Summary.

Astrocytes were long referred to as passive cells in the central nervous system (CNS). However, the application of fluorescent Ca2+ indicators revealed their “Ca2+ excitability” in response to a variety of stimuli. Since then, evidence showing that astrocytes release chemical transmitters and can modulate synapses has led to a new integrative view of the astrocyte. While it is inarguable that astrocytes play essential roles in nervous system function, and that gliotransmission modulates synapses, a significant challenge lies in developing the appropriate experimental strategy to allow unequivocal identification of roles for gliotransmission in nervous system function.