Journal of Neural Transmission

, Volume 111, Issue 2, pp 217–221

Association analysis of the −308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia

  • R. Hashimoto
  • M. Yoshida
  • N. Ozaki
  • Y. Yamanouchi
  • N. Iwata
  • T. Suzuki
  • T. Kitajima
  • M. Tatsumi
  • K. Kamijima
  • H. Kunugi
Short Communication

DOI: 10.1007/s00702-003-0101-z

Cite this article as:
Hashimoto, R., Yoshida, M., Ozaki, N. et al. J Neural Transm (2004) 111: 217. doi:10.1007/s00702-003-0101-z

Summary.

Two research groups have thus far reported a significant association between schizophrenia and a promoter polymorphism (−308G > A) of the gene encoding tumor necrosis factor alpha (TNF-α), while contradictive negative results have also been reported. We examined the possible association in a Japanese sample of 297 schizophrenia cases and 458 controls. Allele frequencies of both the patients and controls were very low (1.5% and 0.8%, respectively), and the difference was not statistically significant. We conclude that the effect of the −308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the −308G > A polymorphism of the TNF-α gene.

Keywords: Schizophrenia, tumor necrosis factor α, association study, genetics, single nucleotide polymorphism (SNP), promoter 

Copyright information

© Springer-Verlag/Wien 2004

Authors and Affiliations

  • R. Hashimoto
    • 1
  • M. Yoshida
    • 1
  • N. Ozaki
    • 2
  • Y. Yamanouchi
    • 3
  • N. Iwata
    • 3
  • T. Suzuki
    • 3
  • T. Kitajima
    • 3
  • M. Tatsumi
    • 4
  • K. Kamijima
    • 4
  • H. Kunugi
    • 1
  1. 1.Department of Mental Disorder ResearchNational Institute of Neuroscience, National Center of Neurology and PsychiatryTokyoJapan
  2. 2.Department of PsychiatryNagoya University Graduate School of MedicineNagoyaJapan
  3. 3.Department of PsychiatryFujita Health University School of MedicineNagoyaJapan
  4. 4.Department of PsychiatryShowa University School of MedicineTokyoJapan

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