Association analysis of the −308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia
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- Hashimoto, R., Yoshida, M., Ozaki, N. et al. J Neural Transm (2004) 111: 217. doi:10.1007/s00702-003-0101-z
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Two research groups have thus far reported a significant association between schizophrenia and a promoter polymorphism (−308G > A) of the gene encoding tumor necrosis factor alpha (TNF-α), while contradictive negative results have also been reported. We examined the possible association in a Japanese sample of 297 schizophrenia cases and 458 controls. Allele frequencies of both the patients and controls were very low (1.5% and 0.8%, respectively), and the difference was not statistically significant. We conclude that the effect of the −308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the −308G > A polymorphism of the TNF-α gene.