Journal of Neural Transmission

, Volume 110, Issue 9, pp 997–1011

Heart rate variability and Parkinson’s disease severity

  • D. Devos
  • M. Kroumova
  • R. Bordet
  • H. Vodougnon
  • J. D. Guieu
  • C. Libersa
  • A. Destee

DOI: 10.1007/s00702-003-0016-8

Cite this article as:
Devos, D., Kroumova, M., Bordet, R. et al. J Neural Transm (2003) 110: 997. doi:10.1007/s00702-003-0016-8

Summary.

 Heart rate variability (HRV) decrease in Parkinson’s disease (PD) could only be a consequence of reduce motor activity besides of being a marker of cardiovascular dysautonomia. Under continuously recorded and standardised motor activity, we studied thirty patients compared to controls in 3 PD stages: group I: less than 2 year-evolution, slight impaired without L-dopa; group II: mildly impaired with L-dopa; group III: advanced PD with motor complications. No difference was observed between group I and controls. The diurnal low frequency power (LF) and the ratio of LF/high frequency (HF) power decreased in groups II and III. The nocturnal vagal indicators: HF power and pNN50 were decreased in group III. Those parameters were correlated with Off-drug-motor handicap, suggesting an evolutive HRV decrease with disease severity but not with On-drug-motor activity. The low LF despite the higher motor activity in group III, due to dyskinesias, suggested a defective cardiovascular up-regulation.

Keywords: Heart rate variability, Parkinson’s disease, autonomic nervous system, motor activity.

Copyright information

© Springer-Verlag/Wien 2003

Authors and Affiliations

  • D. Devos
    • 1
  • M. Kroumova
    • 2
  • R. Bordet
    • 3
  • H. Vodougnon
    • 2
  • J. D. Guieu
    • 4
  • C. Libersa
    • 2
  • A. Destee
    • 1
  1. 1.Department of Neurology, EA 2683, CHU Lille, FranceFR
  2. 2.Clinical Investigation Center CHU-INSERM, FranceFR
  3. 3.Department of Pharmacology, EA 1046, CHU Lille, FranceFR
  4. 4.Department of Clinical Neurophysiology, EA 2683, CHU Lille, FranceFR