Journal of Neural Transmission

, Volume 110, Issue 8, pp 923-933

Regional serotonin transporter availability and depression are correlated in Wilson’s disease

  • S. HesseAffiliated withClinics for Nuclear Medicine, University Hospital, University of Leipzig, Germany
  • , H. BarthelAffiliated withClinics for Nuclear Medicine, University Hospital, University of Leipzig, Germany
  • , W. HermannAffiliated withClinics for Neurology, University Hospital, University of Leipzig, Germany
  • , T. MuraiAffiliated withDepartment of Psychiatry, Faculty of Medicine, University of Kyoto, Japan
  • , R. KlugeAffiliated withClinics for Nuclear Medicine, University Hospital, University of Leipzig, Germany
  • , A. WagnerAffiliated withClinics for Neurology, University Hospital, University of Leipzig, Germany
  • , O. SabriAffiliated withClinics for Nuclear Medicine, University Hospital, University of Leipzig, Germany
  • , B. EggersAffiliated withClinics for Neurology, University Hospital, University of Leipzig, Germany

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Summary.

 In patients with Wilson’s disease (WD), depression is a frequent psychiatric symptom. In vivo neuroimaging studies suggest that depression and other neuropsychiatric disorders are associated with central serotonergic deficits. However, in vivo measurements of serotonergic neurotransmission have not until now been performed in patients with this copper deposition disorder. The present prospective study revealed that depressive symptomatology is related to an alteration of presynaptic serotonin transporters (SERT) availability as measured by [123I]-2β-carbomethoxy-3β-(iodophenyl)tropane ([123I]β-CIT) and high-resolution single-photon emission computed tomography (SPECT). SERT imaging with [123I]β-CIT-SPECT could therefore become a useful tool for diagnosis and therapy monitoring in depressed WD patients.

Keywords: Wilson’s disease, depression, serotonin transporter, [123I]β-CIT, SPECT.