Journal of Neural Transmission

, Volume 110, Issue 8, pp 923–933

Regional serotonin transporter availability and depression are correlated in Wilson’s disease

Authors

  • S. Hesse
    • Clinics for Nuclear Medicine, University Hospital, University of Leipzig, Germany
  • H. Barthel
    • Clinics for Nuclear Medicine, University Hospital, University of Leipzig, Germany
  • W. Hermann
    • Clinics for Neurology, University Hospital, University of Leipzig, Germany
  • T. Murai
    • Department of Psychiatry, Faculty of Medicine, University of Kyoto, Japan
  • R. Kluge
    • Clinics for Nuclear Medicine, University Hospital, University of Leipzig, Germany
  • A. Wagner
    • Clinics for Neurology, University Hospital, University of Leipzig, Germany
  • O. Sabri
    • Clinics for Nuclear Medicine, University Hospital, University of Leipzig, Germany
  • B. Eggers
    • Clinics for Neurology, University Hospital, University of Leipzig, Germany

DOI: 10.1007/s00702-003-0008-8

Cite this article as:
Hesse, S., Barthel, H., Hermann, W. et al. J Neural Transm (2003) 110: 923. doi:10.1007/s00702-003-0008-8

Summary.

 In patients with Wilson’s disease (WD), depression is a frequent psychiatric symptom. In vivo neuroimaging studies suggest that depression and other neuropsychiatric disorders are associated with central serotonergic deficits. However, in vivo measurements of serotonergic neurotransmission have not until now been performed in patients with this copper deposition disorder. The present prospective study revealed that depressive symptomatology is related to an alteration of presynaptic serotonin transporters (SERT) availability as measured by [123I]-2β-carbomethoxy-3β-(iodophenyl)tropane ([123I]β-CIT) and high-resolution single-photon emission computed tomography (SPECT). SERT imaging with [123I]β-CIT-SPECT could therefore become a useful tool for diagnosis and therapy monitoring in depressed WD patients.

Keywords: Wilson’s disease, depression, serotonin transporter, [123I]β-CIT, SPECT.

Copyright information

© Springer-Verlag/Wien 2003