Journal of Neural Transmission

, Volume 110, Issue 5, pp 537-543

First online:

Preserved memory traces within diencephalic amnesia

  • P. WallaAffiliated with Department of Clinical Neurology, and
  • , J. P. LehrnerAffiliated with Department of Clinical Neurology, and
  • , C. NaselAffiliated with Department of Clinical Radiodiagnostics, University of Vienna, Vienna, Austria
  • , C. BaumgartnerAffiliated with Department of Clinical Neurology, and
  • , L. DeeckeAffiliated with Department of Clinical Neurology, and
  • , W. LangAffiliated with Department of Clinical Neurology, and

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A male patient with bilateral thalamic lesions (medio-ventral nuclei) was investigated. Despite explicit memory impairments his lexical ability was normal. We recorded magnetic field changes (magnetoencephalography, MEG) during the performance of an animate/inanimate discrimination task in which some words where repeated after long delays. Normally, repeated items are classified significantly faster than their first presentations which is accomplished by an unconscious process called priming. The patient did not show any behavioural evidence of priming but the physiological data indicated preservation of this robust form of memory. Brain activation associated with repetitions was attenuated at early stages. The activity difference was posteriorly distributed which is consistent with previous reports about repetition priming. The present study indicated that the bilateral thalamic lesions of our patient disconnected the information processing stream between the primed information and the behavioural response.

Keywords: Thalamic lesion amnesia repetition priming magnetoencephalography.