Journal of Neural Transmission

, Volume 109, Issue 10, pp 1257–1264

Deep brain stimulation of the subthalamic nucleus versus levodopa challenge in Parkinson's disease: measuring the on- and off-conditions with FDG-PET

Authors

  • R. Hilker
    •  Department of Neurology, and
  • J. Voges
    •  Department of Stereotaxy and Functional Neurosurgery, Medical University of Cologne, and
  • A. Thiel
    •  Department of Neurology, and
  • M. Ghaemi
    •  Department of Neurology, and
  • K. Herholz
    •  Department of Neurology, and
  • V. Sturm
    •  Department of Stereotaxy and Functional Neurosurgery, Medical University of Cologne, and
  • W.-D. Heiss
    •  Department of Neurology, and

DOI: 10.1007/s00702-002-0696-5

Cite this article as:
Hilker, R., Voges, J., Thiel, A. et al. J Neural Transm (2002) 109: 1257. doi:10.1007/s00702-002-0696-5

Summary.

In order to compare the effects of high-frequency stimulation of the subthalamic nucleus (STN-DBS) and a levodopa-challenge on cerebral metabolic activity, we conducted PET scans with [18F]2-fluoro-2-deoxyglucose (FDG) in the drug- and stimulation- on- and off-condition in a single patient suffering from advanced PD. Our data revealed evidence for improved thalamocortical processing released from inhibition by overactive basal ganglia output nuclei in both on-conditions. While levodopa also led to a reduction of lentiform hyperactivity, effective STN stimulation seemed to interfere with distinct cerebellar and limbic circuits.

Keywords: Parkinson's diseasedeep brain stimulationpositron emission tomography (PET).
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Copyright information

© Springer-Verlag Wien 2002