Acta Neurochirurgica

, Volume 141, Issue 3, pp 295–305

Cell-Extracellular Matrix Interaction in Glioma Invasion

  • R. H. Goldbrunner
  • J. J. Bernstein
  • J.-C. Tonn

DOI: 10.1007/s007010050301

Cite this article as:
Goldbrunner, R., Bernstein, J. & Tonn, JC. Acta Neurochir (Wien) (1999) 141: 295. doi:10.1007/s007010050301

 The complex receptor-ECM interaction in glioma cell invasion is discussed focussing upon the role of integrin receptors and matrix-metalloproteinases. Influencing these molecules or their regulation may lead to novel therapeutic approaches in the treatment of malignant glioma.

Keywords: Adhesion; CD44; extracellular matrix; glioma; integrins; invasion; migration. 

Copyright information

© Springer-Verlag Wien 1999

Authors and Affiliations

  • R. H. Goldbrunner
    • 1
  • J. J. Bernstein
    • 2
  • J.-C. Tonn
    • 1
  1. 1.Department of Neurosurgery, University of Würzburg, Würzburg, Germany DE
  2. 2.Department of Veterans Affairs Medical Center, Washington DC 20422