Experimental research

Acta Neurochirurgica

, Volume 152, Issue 9, pp 1583-1590

First online:

Curcumin improves early functional results after experimental spinal cord injury

  • Berker CemilAffiliated withDepartment of Neurosurgery, Faculty of Medicine, Fatih University Email author 
  • , Kivanc TopuzAffiliated withDepartment of Neurosurgery, Haydarpasa Training Hospital, Gulhane Military Medical Academy
  • , Mehmet Nusret DemircanAffiliated withDepartment of Neurosurgery, Haydarpasa Training Hospital, Gulhane Military Medical Academy
  • , Gokhan KurtAffiliated withDepartment of Neurosurgery, Gazi University
  • , Kagan TunAffiliated withDepartment of Neurosurgery, Ankara Numune Education and Research Hospital
  • , Murat KutlayAffiliated withDepartment of Neurosurgery, Haydarpasa Training Hospital, Gulhane Military Medical Academy
  • , Osman IpciogluAffiliated withDepartment of Biochemistry, Haydarpasa Training Hospital, Gulhane Military Medical Academy
  • , Zafer KucukodaciAffiliated withDepartment of Pathology, Haydarpasa Training Hospital, Gulhane Military Medical Academy

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Abstract

Background

Curcumin is a polyphenol extracted from the rhizome of Curcuma longa and well known as a multifunctional drug with anti-oxidative, anticancerous, and anti-inflammatory activities. The aim of the study was to evaluate and compare the effects of the use of the curcumin and the methylprednisolone sodium succinate (MPSS) functionally, biochemically, and pathologically after experimental spinal cord injury (SCI).

Method

Forty rats were randomly allocated into five groups. Group 1 was performed only laminectomy. Group 2 was introduced 70-g closing force aneurysm clip injury. Group 3 was given 30 mg/kg MPSS intraperitoneally immediately after the trauma. Group 4 was given 200 mg/kg of curcumin immediately after the trauma. Group 5 was the vehicle, and immediately after trauma, 1 mL of rice bran oil was injected. The animals were examined by inclined plane score and Basso–Beattie–Bresnahan scale 24 h after the trauma. At the end of the experiment, spinal cord tissue samples were harvested to analyze tissue concentrations of malondialdehyde (MDA) levels, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) activity, and catalase (CAT) activity and pathological evaluation.

Findings

Curcumin treatment improved neurologic outcome, which was supported by decreased level of tissue MDA and increased levels of tissue GSH-Px, SOD, and CAT activity. Light microscopy results also showed preservation of tissue structure in the treatment group.

Conclusions

This study showed the neuroprotective effects of curcumin on experimental SCI model. By increasing tissue levels of GSH-Px, SOD, and CAT, curcumin seems to reduce the effects of injury to the spinal cord, which may be beneficial for neuronal survival.

Keywords

Curcumin Methylprednisolone Neuroprotection Oxygen-free radical Spinal cord injury