Acta Neurochirurgica

, Volume 152, Issue 5, pp 803–815

Operative intervention for delayed symptomatic radionecrotic masses developing following stereotactic radiosurgery for cerebral arteriovenous malformations—case analysis and literature review

  • Mansoor Foroughi
  • Andras A. Kemeny
  • Martin Lehecka
  • Juliana Wons
  • Lisa Kajdi
  • Richard Hatfield
  • Sidney Marks
Case Report

DOI: 10.1007/s00701-009-0581-1

Cite this article as:
Foroughi, M., Kemeny, A.A., Lehecka, M. et al. Acta Neurochir (2010) 152: 803. doi:10.1007/s00701-009-0581-1

Abstract

Case report

We report two cases of operative intervention that was beneficial in the treatment of delayed symptomatic radionecrotic masses that had developed following stereotactic radiosurgery (SRS) using the gamma knife (GK) for the treatment of cerebral arteriovenous malformations (AVM).

Discussion

Case 1 involved a small craniotomy for decompression of a large cerebral multiloculated cyst, which had become symptomatic 84 months following gamma knife treatment for a left frontal lobe AVM. Case 2 involved surgical excision of an occipital radionecrotic mass 72 months following GK treatment for an occipital AVM. This patient had suffered from longstanding symptomatic cerebral oedema, which on occasions had become life threatening. Case 2 is also the first report of a radionecrotic mass occurring post-SRS for an AVM, which conversely appeared to demonstrate increased uptake on single photon emission computed tomography (SPECT) scan. The first literature review of such delayed symptomatic radionecrotic lesions is presented. There appears to be a late onset of symptoms (average 55 months, range 12–111 months) associated with such radionecrosis. Drainage of such cysts or excision of the mass lesion appears to be consistently beneficial to the patients and appears to be uncomplicated.

Conclusion

We recommend early surgical intervention for such delayed symptomatic radionecrotic masses that do not resolve following non-operative management. We also recommend caution in interpretation of SPECT scan results when attempting to differentiate radionecrosis from neoplasia.

Keywords

RadionecrosisArteriovenous malformationGamma knifeStereotactic radiosurgeryComplicationsSPECT

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Mansoor Foroughi
    • 1
  • Andras A. Kemeny
    • 2
  • Martin Lehecka
    • 3
  • Juliana Wons
    • 3
  • Lisa Kajdi
    • 3
  • Richard Hatfield
    • 1
  • Sidney Marks
    • 4
  1. 1.Department of NeurosurgeryUniversity Hospital of Wales CardiffCardiffUK
  2. 2.Department of NeurosurgeryRoyal Hallamshire HospitalSheffieldUK
  3. 3.Department of NeurosurgeryHelsinki University Central HospitalHelsinkiFinland
  4. 4.Department of NeurosurgeryJames Cook University HospitalMiddlesbroughUK