Acta Neurochirurgica

, Volume 152, Issue 3, pp 463–469

A new approach to the treatment of cerebral vasospasm: the angiographic effects of tadalafil on experimental vasospasm

  • Ender Koktekir
  • Yavuz Erdem
  • Mehmet Akif Bayar
  • Cevdet Gokcek
  • Mete Karatay
  • Celal Kilic
Experimental Research

DOI: 10.1007/s00701-009-0540-x

Cite this article as:
Koktekir, E., Erdem, Y., Akif Bayar, M. et al. Acta Neurochir (2010) 152: 463. doi:10.1007/s00701-009-0540-x

Abstract

Background

The pathogenesis of cerebral vasospasm is likely to be multifactorial. Strong evidence has indicated that decreasing levels of NO after SAH seem to be important. A PDE-V inhibitor, tadalafil, theoretically increases NO levels. Our study investigated the vasodilatory efficacy of tadalafil on the cerebral arteries with measurement of basilar artery diameters on angiography.

Methods

We used 42 male Wistar-Albino rats to test our hypothesis. They were assigned randomly into the following seven groups: group 1: control (only saline), group 2: SAH only (killed on day 2), group 3: SAH + tadalafil (killed on day 2), group 4: SAH only (killed on day 4), group 5: SAH + tadalafil (killed on day 4), group 6: saline + tadalafil (killed on day 2) and group 7: saline + tadalafil (killed on day 4). The three different parts of basilar artery diameters were measured angiographically.

Results

There were statistically significant differences between the SAH and SAH groups treated with tadalafil at days 2 and 4. Comparison between control and tadalafil groups showed no significant differences. This result indicated that tadalafil has a vasodilatory effect on vasoconstricted arteries, but no effect on normal basilar arteries.

Conclusion

Our study results showed that tadalafil has a vasodilatory effect on both acute and chronic periods of cerebral vasospasm. We also concluded that cerebral angiography can be used safely for investigation of cerebral vasospasm in animal studies.

Keywords

Cerebral vasospasm Nitric oxide Tadalafil Angiography 

Abbreviations

CSF

cerebrospinal fluid

cGMP

cyclic guanosine monophosphate

DIND

delayed ischemic neurological deficit

EDCF

endothelium-derived constrictor factor

EDRF

endothelium-derived releasing factor

eNOS

endothelial nitric oxide synthase

NO

nitric oxide

PDE-V

phosphodiesterase five

SAH

subarachnoid hemorrhage

TD

tadalafil

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Ender Koktekir
    • 1
    • 2
  • Yavuz Erdem
    • 1
  • Mehmet Akif Bayar
    • 1
  • Cevdet Gokcek
    • 1
  • Mete Karatay
    • 1
  • Celal Kilic
    • 1
  1. 1.Neurosurgery DepartmentMinistry of Health Ankara Education and Research HospitalAnkaraTurkey
  2. 2.Ankara Eğitim ve Araştırma HastanesiNöroşirurji KliniğiAltındağ/AnkaraTurkey

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